User profiles for "author:Ignacio Garcia-Verdugo"
Ignacio Garcia-VerdugoInserm U1152 Université de Paris Cité Verified email at inserm.fr Cited by 1751 |
[HTML][HTML] Pseudomonas aeruginosa LPS or Flagellin Are Sufficient to Activate TLR-Dependent Signaling in Murine Alveolar Macrophages and Airway Epithelial Cells
E Raoust, V Balloy, I Garcia-Verdugo, L Touqui… - PloS one, 2009 - journals.plos.org
Background The human lung is exposed to a large number of airborne pathogens as a
result of the daily inhalation of 10,000 liters of air. Innate immunity is thus essential to defend …
result of the daily inhalation of 10,000 liters of air. Innate immunity is thus essential to defend …
IL-33 enhances lipopolysaccharide-induced inflammatory cytokine production from mouse macrophages by regulating lipopolysaccharide receptor complex
Q Espinassous, E Garcia-de-Paco… - The Journal of …, 2009 - journals.aai.org
Bacterial LPS triggers monocytes and macrophages to produce several inflammatory
cytokines and mediators. However, once exposed to LPS, they become hyporesponsive to a …
cytokines and mediators. However, once exposed to LPS, they become hyporesponsive to a …
The WAP protein Trappin-2/Elafin: a handyman in the regulation of inflammatory and immune responses
T Verrier, B Solhonne, JM Sallenave… - The international journal …, 2012 - Elsevier
Trappin-2/Elafin is a potent serine protease inhibitor which prevents excessive damage
under inflammatory status. This “alarm-antiprotease” is locally expressed by epithelial cells …
under inflammatory status. This “alarm-antiprotease” is locally expressed by epithelial cells …
Pseudomonas aeruginosa LasB protease impairs innate immunity in mice and humans by targeting a lung epithelial cystic fibrosis transmembrane regulator–IL-6 …
V Saint-Criq, B Villeret, F Bastaert, S Kheir, A Hatton… - Thorax, 2018 - thorax.bmj.com
Background Pseudomonas aeruginosa lung infections are a huge problem in ventilator-
associated pneumonia, cystic fibrosis (CF) and in chronic obstructive pulmonary disease …
associated pneumonia, cystic fibrosis (CF) and in chronic obstructive pulmonary disease …
Influenza A induces the major secreted airway mucin MUC5AC in a protease–EGFR–extracellular regulated kinase–Sp1–dependent pathway
D Barbier, I Garcia-Verdugo, J Pothlichet… - American journal of …, 2012 - atsjournals.org
Mucins, the main glycoproteins present within mucus, modulate the rheologic properties of
airways and participate in lung defense. They are thought to be able to trap and eliminate …
airways and participate in lung defense. They are thought to be able to trap and eliminate …
Silver nanoparticle-adjuvanted vaccine protects against lethal influenza infection through inducing BALT and IgA-mediated mucosal immunity
D Sanchez-Guzman, P Le Guen, B Villeret, N Sola… - Biomaterials, 2019 - Elsevier
Most of current influenza virus vaccines fail to develop a strong immunity at lung mucosae
(site of viral entry) due to sub-optimal vaccination protocols (eg inactivated virus …
(site of viral entry) due to sub-optimal vaccination protocols (eg inactivated virus …
Interactions between LPS and lung surfactant proteins
R Chaby, I Garcia-Verdugo… - Journal of …, 2005 - journals.sagepub.com
After penetration into the lower airways, bacterial lipopolysaccharide (LPS) interacts with
alveolar cells in a fluid environment consisting of pulmonary surfactant, a lipid—protein …
alveolar cells in a fluid environment consisting of pulmonary surfactant, a lipid—protein …
Silver nanoparticles impair retinoic acid-inducible gene I-mediated mitochondrial antiviral immunity by blocking the autophagic flux in lung epithelial cells
B Villeret, A Dieu, M Straube, B Solhonne, P Miklavc… - ACS …, 2018 - ACS Publications
Silver nanoparticles (AgNPs) are microbicidal agents which could be potentially used as an
alternative to antivirals to treat human infectious diseases, especially influenza virus …
alternative to antivirals to treat human infectious diseases, especially influenza virus …
Lung protease/anti-protease network and modulation of mucus production and surfactant activity
I Garcia-Verdugo, D Descamps, M Chignard, L Touqui… - Biochimie, 2010 - Elsevier
Lung epithelium guarantees gas-exchange (performed in the alveoli) and protects from
external insults (pathogens, pollutants…) present within inhaled air. Both functions are …
external insults (pathogens, pollutants…) present within inhaled air. Both functions are …
[HTML][HTML] The crystal structure of the Bacillus anthracis spore surface protein BclA shows remarkable similarity to mammalian proteins
S Réty, S Salamitou, I Garcia-Verdugo… - Journal of Biological …, 2005 - ASBMB
The lethal disease anthrax is propagated by spores of Bacillus anthracis, which can
penetrate into the mammalian host by inhalation, causing a rapid progression of the disease …
penetrate into the mammalian host by inhalation, causing a rapid progression of the disease …