User profiles for "author:I. Pavord"
Ian PavordUniversity of Oxford Verified email at ndm.ox.ac.uk Cited by 87776 |
Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease: the GOLD science committee report 2019
Precision medicine is a patient-specific approach that integrates all relevant clinical, genetic
and biological information in order to optimise the therapeutic benefit relative to the …
and biological information in order to optimise the therapeutic benefit relative to the …
After asthma: redefining airways diseases
Executive summary Asthma is responsible for considerable global morbidity and health-care
costs. Substantial progress was made against key outcomes such as hospital admissions …
costs. Substantial progress was made against key outcomes such as hospital admissions …
Prevalence, pathogenesis, and causes of chronic cough
Cough is a reflex action of the respiratory tract that is used to clear the upper airways.
Chronic cough lasting for more than 8 weeks is common in the community. The causes …
Chronic cough lasting for more than 8 weeks is common in the community. The causes …
Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial
Background Some patients with severe asthma have recurrent asthma exacerbations
associated with eosinophilic airway inflammation. Early studies suggest that inhibition of …
associated with eosinophilic airway inflammation. Early studies suggest that inhibition of …
Cluster analysis and clinical asthma phenotypes
Rationale: Heterogeneity in asthma expression is multidimensional, including variability in
clinical, physiologic, and pathologic parameters. Classification requires consideration of …
clinical, physiologic, and pathologic parameters. Classification requires consideration of …
[HTML][HTML] Mepolizumab treatment in patients with severe eosinophilic asthma
Background Some patients with severe asthma have frequent exacerbations associated with
persistent eosinophilic inflammation despite continuous treatment with high-dose inhaled …
persistent eosinophilic inflammation despite continuous treatment with high-dose inhaled …
Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial
RH Green, CE Brightling, S McKenna, B Hargadon… - The Lancet, 2002 - thelancet.com
Background Treatment decisions in asthma are based on assessments of symptoms and
simple measures of lung function, which do not relate closely to underlying eosinophilic …
simple measures of lung function, which do not relate closely to underlying eosinophilic …
[HTML][HTML] Mepolizumab and exacerbations of refractory eosinophilic asthma
P Haldar, CE Brightling, B Hargadon… - New England journal …, 2009 - Mass Medical Soc
Background Exacerbations of asthma are associated with substantial morbidity and mortality
and with considerable use of health care resources. Preventing exacerbations remains an …
and with considerable use of health care resources. Preventing exacerbations remains an …
An official American Thoracic Society/European Respiratory Society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials …
HK Reddel, DR Taylor, ED Bateman… - American journal of …, 2009 - atsjournals.org
Background: The assessment of asthma control is pivotal to the evaluation of treatment
response in individuals and in clinical trials. Previously, asthma control, severity, and …
response in individuals and in clinical trials. Previously, asthma control, severity, and …
[HTML][HTML] Oral glucocorticoid-sparing effect of mepolizumab in eosinophilic asthma
EH Bel, SE Wenzel, PJ Thompson… - New England journal …, 2014 - Mass Medical Soc
Background Many patients with severe asthma require regular treatment with oral
glucocorticoids despite the use of high-dose inhaled therapy. However, the regular use of …
glucocorticoids despite the use of high-dose inhaled therapy. However, the regular use of …