Airflow limitation and airway dimensions in chronic obstructive pulmonary disease

M Hasegawa, Y Nasuhara, Y Onodera… - American journal of …, 2006 - atsjournals.org
Rationale: Chronic obstructive pulmonary disease (COPD) is characterized by airflow
limitation caused by emphysema and/or airway narrowing. Computed tomography has been …

Annual change in pulmonary function and clinical phenotype in chronic obstructive pulmonary disease

M Nishimura, H Makita, K Nagai, S Konno… - American journal of …, 2012 - atsjournals.org
Rationale: Although the rate of annual decline in FEV1 is one of the most important outcome
measures in chronic obstructive pulmonary disease (COPD), little is known about …

Characterisation of phenotypes based on severity of emphysema in chronic obstructive pulmonary disease

H Makita, Y Nasuhara, K Nagai, Y Ito, M Hasegawa… - Thorax, 2007 - thorax.bmj.com
Background: Airflow limitation in chronic obstructive pulmonary disease (COPD) is caused
by a mixture of small airway disease and emphysema, the relative contributions of which …

Association between dietary iodine intake and prevalence of subclinical hypothyroidism in the coastal regions of Japan

N Konno, H Makita, K Yuri, N Iizuka… - The Journal of Clinical …, 1994 - academic.oup.com
The prevalence of thyroid dysfunction in relation to iodine intake was studied in adults (n=
1061) in five coastal areas of Japan that produce iodine-rich seaweed (kelp). The …

Asthma-like features and clinical course of chronic obstructive pulmonary disease. An analysis from the Hokkaido COPD cohort study

M Suzuki, H Makita, S Konno, K Shimizu… - American Journal of …, 2016 - atsjournals.org
Rationale: Some patients with chronic obstructive pulmonary disease (COPD) have asthma-
like features, such as significant bronchodilator reversibility, blood eosinophilia, and/or …

Effect of anti-macrophage migration inhibitory factor antibody on lipopolysaccharide-induced pulmonary neutrophil accumulation

H Makita, M Nishimura, K Miyamoto… - American journal of …, 1998 - atsjournals.org
Macrophage migration inhibitory factor (MIF) is a recently rediscovered pro-inflammatory
cytokine that has the unique potential to override the anti-inflammatory action of …

Clinical features and determinants of COPD exacerbation in the Hokkaido COPD cohort study

M Suzuki, H Makita, YM Ito, K Nagai… - European …, 2014 - Eur Respiratory Soc
Exacerbations are among the major factors that may affect the natural history of chronic
obstructive pulmonary disease (COPD). The aim was to investigate the clinical …

Tissue hypoxia in sleep apnea syndrome assessed by uric acid and adenosine

H Saito, M Nishimura, E Shibuya, H Makita, I Tsujino… - Chest, 2002 - Elsevier
Study objective Although the overnight increase in urinary uric acid/creatinine ratio (ΔUA/Cr)
is considered by some to be a marker of tissue hypoxia in patients with obstructive sleep …

Plasma concentration of adenosine during normoxia and moderate hypoxia in humans

H Saito, M Nishimura, H Shinano, H Makita… - American journal of …, 1999 - atsjournals.org
Adenosine, a purine nucleoside, plays a variety of roles in cardiovascular and ventilatory
control, and may be a marker of tissue hypoxia. There is, however, no direct evidence of an …

Distinct phenotypes of smokers with fixed airflow limitation identified by cluster analysis of severe asthma

S Konno, N Taniguchi, H Makita… - Annals of the …, 2018 - atsjournals.org
Rationale: Smoking may have multifactorial effects on asthma phenotypes, particularly in
severe asthma. Cluster analysis has been applied to explore novel phenotypes, which are …