[HTML][HTML] Surfactant proteins A and D: disease markers

Y Kuroki, H Takahashi, H Chiba, T Akino - Biochimica et Biophysica Acta …, 1998 - Elsevier
The abundant and restricted expression of surfactant proteins SP-A and SP-D within the
lung makes these collectins specific markers for lung diseases. The measurement of SP-A …

Pulmonary surfactant proteins A and D: innate immune functions and biomarkers for lung diseases

H Takahashi, H Sano, H Chiba… - Current pharmaceutical …, 2006 - ingentaconnect.com
Pulmonary surfactant, a complex of lipids and proteins, functions to keep alveoli from
collapsing at expiration. Surfactant proteins A (SP-A) and D (SP-D) belong to the collectin …

Epidemiologic survey of Japanese patients with idiopathic pulmonary fibrosis and investigation of ethnic differences

M Natsuizaka, H Chiba, K Kuronuma… - American journal of …, 2014 - atsjournals.org
Rationale: Idiopathic pulmonary fibrosis (IPF) has an unknown etiology and poor prognosis.
Several large-scale epidemiologic studies have been conducted predominantly in Western …

Significance of molecular biomarkers in idiopathic pulmonary fibrosis: a mini review

H Chiba, M Otsuka, H Takahashi - Respiratory investigation, 2018 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic, irreversible condition with poor prognosis
that is characterized by a variable clinical course in each patient, which renders it a complex …

Mutations in the SLC34A2 Gene Are Associated with Pulmonary Alveolar Microlithiasis

Huqun, S Izumi, H Miyazawa, K Ishii… - American journal of …, 2007 - atsjournals.org
Rationale: Pulmonary alveolar microlithiasis is an autosomal recessive disorder in which
microliths are formed in the alveolar space. Objectives: To identify the responsible gene that …

[HTML][HTML] Surfactant proteins A and D bind CD14 by different mechanisms

H Sano, H Chiba, D Iwaki, H Sohma, DR Voelker… - Journal of Biological …, 2000 - ASBMB
Surfactant proteins A (SP-A) and D (SP-D) are lung collectins that are constituents of the
innate immune system of the lung. Recent evidence (Sano, H., Sohma, H., Muta, T., Nomura …

Serum levels of surfactant proteins A and D are useful biomarkers for interstitial lung disease in patients with progressive systemic sclerosis

H Takahashi, Y Kuroki, H Tanaka, T SAITO… - American journal of …, 2000 - atsjournals.org
To find a less-invasive and lung-specific clinical biomarker, we measured serum levels of
surfactant proteins A and D (SP-A and SP-D) by sandwich enzyme-linked immunosorbent …

[HTML][HTML] Genome editing in the mushroom-forming basidiomycete Coprinopsis cinerea, optimized by a high-throughput transformation system

SS Sugano, H Suzuki, E Shimokita, H Chiba, S Noji… - Scientific reports, 2017 - nature.com
Mushroom-forming basidiomycetes produce a wide range of metabolites and have great
value not only as food but also as an important global natural resource. Here, we …

[HTML][HTML] Impaired diversity of the lung microbiome predicts progression of idiopathic pulmonary fibrosis

Y Takahashi, A Saito, H Chiba, K Kuronuma… - Respiratory …, 2018 - Springer
Background Idiopathic pulmonary fibrosis (IPF) is the most frequent and severe form of
idiopathic interstitial pneumonias. Although IPF has not been thought to be associated with …

[HTML][HTML] Poorer prognosis of idiopathic pleuroparenchymal fibroelastosis compared with idiopathic pulmonary fibrosis in advanced stage

M Shioya, M Otsuka, G Yamada, Y Umeda… - Canadian respiratory …, 2018 - hindawi.com
Objective. Idiopathic pleuroparenchymal fibroelastosis (IPPFE) is a rare disease
characterized by predominant upper lobe pulmonary fibrosis of unknown etiology. However …