[PDF][PDF] Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function

BLM Hogan, CE Barkauskas, HA Chapman, JA Epstein… - Cell stem cell, 2014 - cell.com
Respiratory disease is the third leading cause of death in the industrialized world.
Consequently, the trachea, lungs, and cardiopulmonary vasculature have been the focus of …

Emerging roles for cysteine proteases in human biology

HA Chapman, RJ Riese, GP Shi - Annual review of physiology, 1997 - annualreviews.org
▪ Abstract Cysteine proteases have traditionally been viewed as lysosomal mediators of
terminal protein degradation. However, recent findings refute this limited view and suggest a …

[PDF][PDF] The cellular and physiological basis for lung repair and regeneration: past, present, and future

MC Basil, J Katzen, AE Engler, M Guo, MJ Herriges… - Cell stem cell, 2020 - cell.com
The respiratory system, which includes the trachea, airways, and distal alveoli, is a complex
multi-cellular organ that intimately links with the cardiovascular system to accomplish gas …

Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix

KK Kim, MC Kugler, PJ Wolters… - Proceedings of the …, 2006 - National Acad Sciences
Mechanisms leading to fibroblast accumulation during pulmonary fibrogenesis remain
unclear. Although there is in vitro evidence of lung alveolar epithelial-to-mesenchymal …

In bad taste: Evidence for the oral origins of moral disgust

HA Chapman, DA Kim, JM Susskind, AK Anderson - Science, 2009 - science.org
In common parlance, moral transgressions “leave a bad taste in the mouth.” This metaphor
implies a link between moral disgust and more primitive forms of disgust related to toxicity …

Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency

BD Gelb, GP Shi, HA Chapman, RJ Desnick - Science, 1996 - science.org
Pycnodysostosis, an autosomal recessive osteochondrodysplasia characterized by
osteosclerosis and short stature, maps to chromosome 1q21. Cathepsin K, a cysteine …

[HTML][HTML] Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis

M Strunz, LM Simon, M Ansari, JJ Kathiriya… - Nature …, 2020 - nature.com
The cell type specific sequences of transcriptional programs during lung regeneration have
remained elusive. Using time-series single cell RNA-seq of the bleomycin lung injury model …

[HTML][HTML] Cystatin C deficiency in human atherosclerosis and aortic aneurysms

GP Shi, GK Sukhova, A Grubb… - The Journal of …, 1999 - Am Soc Clin Investig
The pathogenesis of atherosclerosis and abdominal aortic aneurysm involves breakdown of
the elastic laminae. Elastolytic cysteine proteases, including cathepsins S and K, are …

[PDF][PDF] Essential role for cathepsin S in MHC class II–associated invariant chain processing and peptide loading

RJ Riese, PR Wolf, D Brömme, LR Natkin… - Immunity, 1996 - cell.com
Destruction of Ii by proteolysis is required for MHC class II molecules to bind antigenic
peptides, and for transport of the resulting complexes to the cell surface. The cysteine …

[HTML][HTML] Cathepsin S required for normal MHC class II peptide loading and germinal center development

GP Shi, JA Villadangos, G Dranoff, C Small, L Gu… - Immunity, 1999 - cell.com
Major histocompatibility complex (MHC) class II molecules acquire antigenic peptides after
degradation of the invariant chain (Ii), an MHC class II–associated protein that otherwise …