Purpose This study aimed to assess the prevalence and time course of asynchronies during
mechanical ventilation (MV). Methods Prospective, noninterventional observational study of …

Background More than 20% of hospitalized patients with COVID-19 demonstrate ARDS
requiring ICU admission. The long-term respiratory sequelae in such patients remain …

Acute lung injury (ALI) is a clinical syndrome characterized by impairment in gas exchange
and/or lung mechanics that leads to hypoxemia and increased work of breathing (WOB) …

Neutrophils are key players in acute lung injury. Once recruited from the circulation, these
cells release cytotoxic molecules that lead to tissue disruption, so their blockade has been …

The Angiotensin system is implicated in the pathogenesis of COVID-19. First, ACE2 is the
cellular receptor for SARS-CoV-2, and expression of the ACE2 gene could regulate the …

Advancements in methods, technology, and our understanding of the pathobiology of lung
injury have created the need to update the definition of experimental acute lung injury (ALI) …

Ventilator-induced lung injury (VILI) consists of tissue damage and a biological response
resulting from the application of inappropriate mechanical forces to the lung parenchyma …

Background and aims The interferon-induced transmembrane proteins play an important
antiviral role by preventing viruses from traversing the cellular lipid bilayer. IFITM3 gene …

Background Matrix metalloproteinases (MMPs) may have pro and antifibrotic roles within the
lungs, due to its ability to modulate collagen turnover and immune mediators. MMP-8 is a …

The inflection points of the pressure–volume curve have been used for setting mechanical
ventilation in patients with acute lung injury. However, the lung status at these points has …