User profiles for "author:Gerard H Koppelman"

Gerard H. Koppelman

Professor of Pediatric Pulmonology, University Medical Center Groningen
Verified email at umcg.nl
Cited by 32786

Biologic therapies for severe asthma

GG Brusselle, GH Koppelman - New England Journal of …, 2022 - Mass Medical Soc
Biologic Therapies for Severe Asthma Patients with severe asthma are at increased risk for a
decreased quality of life, fixed airway obstruction, hospitalization, and death. Biologics may …

Allergic Rhinitis and its Impact on Asthma (ARIA): achievements in 10 years and future needs

J Bousquet, HJ Schünemann, B Samolinski… - Journal of Allergy and …, 2012 - Elsevier
Allergic rhinitis (AR) and asthma represent global health problems for all age groups.
Asthma and rhinitis frequently coexist in the same subjects. Allergic Rhinitis and its Impact …

MACVIA‐ARIA Sentinel NetworK for allergic rhinitis (MASK‐rhinitis): the new generation guideline implementation

J Bousquet, HJ Schunemann, J Fonseca… - Allergy, 2015 - Wiley Online Library
Several unmet needs have been identified in allergic rhinitis: identification of the time of
onset of the pollen season, optimal control of rhinitis and comorbidities, patient stratification …

Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction

DF Gudbjartsson, US Bjornsdottir, E Halapi… - Nature …, 2009 - nature.com
Eosinophils are pleiotropic multifunctional leukocytes involved in initiation and propagation
of inflammatory responses and thus have important roles in the pathogenesis of …

[PDF][PDF] DNA methylation in newborns and maternal smoking in pregnancy: genome-wide consortium meta-analysis

BR Joubert, JF Felix, P Yousefi, KM Bakulski… - The American Journal of …, 2016 - cell.com
Epigenetic modifications, including DNA methylation, represent a potential mechanism for
environmental impacts on human disease. Maternal smoking in pregnancy remains an …

A cellular census of human lungs identifies novel cell states in health and in asthma

FA Vieira Braga, G Kar, M Berg, OA Carpaij… - Nature medicine, 2019 - nature.com
Human lungs enable efficient gas exchange and form an interface with the environment,
which depends on mucosal immunity for protection against infectious agents. Tightly …

[HTML][HTML] Patterns of growth and decline in lung function in persistent childhood asthma

MJ McGeachie, KP Yates, X Zhou, F Guo… - … England Journal of …, 2016 - Mass Medical Soc
Background Tracking longitudinal measurements of growth and decline in lung function in
patients with persistent childhood asthma may reveal links between asthma and subsequent …

Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis

JS Ried, J Li, XB Zuo, XD Zheng, XY Yin, LD Sun… - Nature …, 2015 - nature.com
Genetic association studies have identified 21 loci associated with atopic dermatitis risk
predominantly in populations of European ancestry. To identify further susceptibility loci for …

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

F Demenais, P Margaritte-Jeannin, KC Barnes… - Nature …, 2018 - nature.com
We examined common variation in asthma risk by conducting a meta-analysis of worldwide
asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of …

Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology

MA Ferreira, JM Vonk, H Baurecht, I Marenholz… - Nature …, 2017 - nature.com
Asthma, hay fever (or allergic rhinitis) and eczema (or atopic dermatitis) often coexist in the
same individuals, partly because of a shared genetic origin,,. To identify shared risk variants …