Current and future therapies for Pseudomonas aeruginosa infection in patients with cystic fibrosis
WD Smith, E Bardin, L Cameron… - FEMS microbiology …, 2017 - academic.oup.com
Pseudomonas aeruginosa opportunistically infects the airways of patients with cystic fibrosis
and causes significant morbidity and mortality. Initial infection can often be eradicated …
and causes significant morbidity and mortality. Initial infection can often be eradicated …
Airway microbiome and development of bronchopulmonary dysplasia in preterm infants: a systematic review
Objectives To summarize evidence regarding microbial dysbiosis of the airway associated
with bronchopulmonary dysplasia (BPD) and to explore heterogeneity among studies. Study …
with bronchopulmonary dysplasia (BPD) and to explore heterogeneity among studies. Study …
[HTML][HTML] Dysfunctional breathing in children and adults with asthma
GJ Connett, M Thomas - Frontiers in pediatrics, 2018 - frontiersin.org
Asthma occurs across the life course. Its optimal treatment includes the use of personalized
management plans that recognize the importance of co-morbidities including so-called …
management plans that recognize the importance of co-morbidities including so-called …
[HTML][HTML] Standards of care for CFTR variant-specific therapy (including modulators) for people with cystic fibrosis
KW Southern, C Castellani, E Lammertyn… - Journal of Cystic …, 2023 - Elsevier
Cystic fibrosis (CF) has entered the era of variant-specific therapy, tailored to the genetic
variants in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene. CFTR …
variants in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene. CFTR …
Cephalosporin nitric oxide-donor prodrug DEA-C3D disperses biofilms formed by clinical cystic fibrosis isolates of Pseudomonas aeruginosa
O Soren, A Rineh, DG Silva, Y Cai… - Journal of …, 2020 - academic.oup.com
Objectives The cephalosporin nitric oxide (NO)-donor prodrug DEA-C3D ('DiEthylAmin-
Cephalosporin-3′-Diazeniumdiolate') has been shown to initiate the dispersal of biofilms …
Cephalosporin-3′-Diazeniumdiolate') has been shown to initiate the dispersal of biofilms …
[HTML][HTML] Molecular microbiological characterization of preterm neonates at risk of bronchopulmonary dysplasia
The role of infection in bronchopulmonary dysplasia (BPD) is unknown. We present an
observational study of 55 premature infants born weighing less than 1.3 kg within two level …
observational study of 55 premature infants born weighing less than 1.3 kg within two level …
Use of budesonide in severe asthmatics aged 1-3 years.
GJ Connett, C Warde, E Wooler… - Archives of disease in …, 1993 - adc.bmj.com
The treatment of severe asthmatics aged 1-3 years with budesonide administered via
Nebuhaler and Laerdal facemask was assessed in a six month, double blind, placebo …
Nebuhaler and Laerdal facemask was assessed in a six month, double blind, placebo …
Projecting the impact of triple CFTR modulator therapy on intravenous antibiotic requirements in cystic fibrosis using patient registry data combined with treatment …
Background Cystic fibrosis (CF) is a life-threatening genetic disease, affecting around 10
500 people in the UK. Precision medicines have been developed to treat specific CF-gene …
500 people in the UK. Precision medicines have been developed to treat specific CF-gene …
Cephalosporin-3′-diazeniumdiolate NO donor prodrug PYRRO-C3D enhances azithromycin susceptibility of nontypeable Haemophilus influenzae biofilms
ABSTRACT PYRRO-C3D is a cephalosporin-3-diazeniumdiolate nitric oxide (NO) donor
prodrug designed to selectively deliver NO to bacterial infection sites. The objective of this …
prodrug designed to selectively deliver NO to bacterial infection sites. The objective of this …
[HTML][HTML] Studying bacteria in respiratory specimens by using conventional and molecular microbiological approaches
Background Drawing from previous studies, the traditional routine diagnostic microbiology
evaluation of samples from chronic respiratory conditions may provide an incomplete picture …
evaluation of samples from chronic respiratory conditions may provide an incomplete picture …