[HTML][HTML] Neutrophil extracellular traps in inflammatory bowel disease: pathogenic mechanisms and clinical translation
B Drury, G Hardisty, RD Gray, G Ho - Cellular and molecular …, 2021 - Elsevier
Abstract The Inflammatory Bowel Diseases (IBD), Ulcerative Colitis (UC) and Crohn's
Disease (CD) are characterised by chronic non-resolving gut mucosal inflammation …
Disease (CD) are characterised by chronic non-resolving gut mucosal inflammation …
Delayed neutrophil apoptosis enhances NET formation in cystic fibrosis
RD Gray, G Hardisty, KH Regan, M Smith, CT Robb… - Thorax, 2018 - thorax.bmj.com
Background Cystic fibrosis (CF) lung disease is defined by large numbers of neutrophils and
associated damaging products in the airway. Delayed neutrophil apoptosis is described in …
associated damaging products in the airway. Delayed neutrophil apoptosis is described in …
[HTML][HTML] The neutrophil antimicrobial peptide cathelicidin promotes Th17 differentiation
D Minns, KJ Smith, V Alessandrini, G Hardisty… - Nature …, 2021 - nature.com
The host defence peptide cathelicidin (LL-37 in humans, mCRAMP in mice) is released from
neutrophils by de-granulation, NETosis and necrotic death; it has potent anti-pathogen …
neutrophils by de-granulation, NETosis and necrotic death; it has potent anti-pathogen …
An inhaled galectin-3 inhibitor in COVID-19 pneumonitis: a phase Ib/IIa randomized controlled clinical trial (DEFINE)
EE Gaughan, TM Quinn, A Mills, AM Bruce… - American Journal of …, 2023 - atsjournals.org
Rationale: High circulating galectin-3 is associated with poor outcomes in patients with
coronavirus disease (COVID-19). We hypothesized that GB0139, a potent inhaled …
coronavirus disease (COVID-19). We hypothesized that GB0139, a potent inhaled …
[HTML][HTML] High purity isolation of low density neutrophils casts doubt on their exceptionality in health and disease
GR Hardisty, F Llanwarne, D Minns, JL Gillan… - Frontiers in …, 2021 - frontiersin.org
Low density neutrophils (LDNs) are described in a number of inflammatory conditions,
cancers and infections and associated with immunopathology, and a mechanistic role in …
cancers and infections and associated with immunopathology, and a mechanistic role in …
[HTML][HTML] The outcome of neutrophil-T cell contact differs depending on activation status of both cell types
D Minns, KJ Smith, G Hardisty, AG Rossi… - Frontiers in …, 2021 - frontiersin.org
Neutrophils and T cells exist in close proximity in lymph nodes and inflamed tissues during
health and disease. They are able to form stable interactions, with profound effects on the …
health and disease. They are able to form stable interactions, with profound effects on the …
[HTML][HTML] Randomised controlled trial of intravenous nafamostat mesylate in COVID pneumonitis: Phase 1b/2a experimental study to investigate safety …
TM Quinn, EE Gaughan, A Bruce, J Antonelli… - …, 2022 - thelancet.com
Background Many repurposed drugs have progressed rapidly to Phase 2 and 3 trials in
COVID19 without characterisation of Pharmacokinetics/Pharmacodynamics including safety …
COVID19 without characterisation of Pharmacokinetics/Pharmacodynamics including safety …
Role of the B allele of influenza A virus segment 8 in setting mammalian host range and pathogenicity
ML Turnbull, HM Wise, MQ Nicol, N Smith… - Journal of …, 2016 - Am Soc Microbiol
Two alleles of segment 8 (NS) circulate in nonchiropteran influenza A viruses. The A allele is
found in avian and mammalian viruses, but the B allele is viewed as being almost …
found in avian and mammalian viruses, but the B allele is viewed as being almost …
[HTML][HTML] Human cystic fibrosis monocyte derived macrophages display no defect in acidification of phagolysosomes when measured by optical nanosensors
SM Law, SJ Stanfield, GR Hardisty, I Dransfield… - Journal of Cystic …, 2020 - Elsevier
Background Defective macrophage phagolysosomal acidification is implicated in numerous
lung diseases including Cystic Fibrosis (CF) and may contribute to defective pathogen …
lung diseases including Cystic Fibrosis (CF) and may contribute to defective pathogen …
[HTML][HTML] Concurrent Infection With the Filarial Helminth Litomosoides sigmodontis Attenuates or Worsens Influenza A Virus Pathogenesis in a Stage-Dependent …
GR Hardisty, JA Knipper, A Fulton, J Hopkins… - Frontiers in …, 2022 - frontiersin.org
Filarial helminths infect approximately 120 million people worldwide initiating a type 2
immune response in the host. Influenza A viruses stimulate a virulent type 1 pro …
immune response in the host. Influenza A viruses stimulate a virulent type 1 pro …