Immunohistochemical characterization of the pancreatic cellular infiltrate in normal pancreas, chronic pancreatitis and pancreatic carcinoma

J Emmrich, I Weber, M Nausch, G Sparmann, K Koch… - Digestion, 1998 - karger.com
Abstract Background/Aims: Chronic pancreatitis is histologically characterized by an
extended fibrosis and infiltration of leukocytes. We intended to differentiate the infiltration to …

Extracellular signal regulated kinases are key mediators of mitogenic signals in rat pancreatic stellate cells

R Jaster, G Sparmann, J Emmrich, S Liebe - Gut, 2002 - gut.bmj.com
Background: Pancreatic stellate cells (PSCs) have been implicated in pancreatic fibrosis as
they synthesise increased amounts of extracellular matrix proteins in response to activation …

Pancreatic fibrosis in experimental pancreatitis induced by dibutyltin dichloride

G Sparmann, J Merkord, A Jaschke, H Nizze, L Jonas… - Gastroenterology, 1997 - Elsevier
BACKGROUND & AIMS: Regulatory mechanisms in chronic pancreatitis finally resulting in
pancreatic fibrosis cannot be studied sufficiently in human pancreas. Results of a new …

Regulation of pancreatic stellate cell function in vitro: biological and molecular effects of all-trans retinoic acid

…, I Hilgendorf, B Fitzner, P Brock, G Sparmann… - Biochemical …, 2003 - Elsevier
Pancreatic stellate cells (PSCs) are essentially involved in the development of pancreatic
fibrosis, a constant feature of chronic pancreatitis and pancreatic cancer. Profibrogenic …

Biochemistry of liver development in the perinatal period

HJ Böhme, G Sparmann, E Hofmann - Experientia, 1983 - Springer
Just before birth, changes occur in the metabolic capacities of rat liver so that the animal can
adapt to changes in the substrate supply. In utero, glucose is the main energy-generating …

[HTML][HTML] Bone marrow-derived pancreatic stellate cells in rats

G Sparmann, ML Kruse, N Hofmeister-Mielke… - Cell research, 2010 - nature.com
Origin and fate of pancreatic stellate cells (PSCs) before, during and after pancreatic injury
are a matter of debate. The crucial role of PSCs in the pathogenesis of pancreatic fibrosis is …

Generation and characterization of immortalized rat pancreatic stellate cells

G Sparmann, C Hohenadl, J Tornøe… - American Journal …, 2004 - journals.physiology.org
Pancreatic stellate cells (PSCs) are involved in, among other things, the pathogenesis of
pancreatic fibrosis. Here, we present the generation of immortalized PSCs 7 and 14 days …

Peroxisome proliferator‐activated receptor γ overexpression inhibits pro‐fibrogenic activities of immortalised rat pancreatic stellate cells

…, D Koczan, HJ Thiesen, G Sparmann… - Journal of cellular …, 2005 - Wiley Online Library
Pancreatic stellate cells (PSCs) play a key role in the development of pancreatic fibrosis, a
constant feature of chronic pancreatitis and pancreatic cancer. In response to pro‐fibrogenic …

Caerulein pancreatitis increases mRNA but reduces protein levels of rat pancreatic heat shock proteins

MZ Strowski, G Sparmann, H Weber… - American Journal …, 1997 - journals.physiology.org
We have recently reported that preconditioning through hyperthermia induces expression of
pancreatic heat shock proteins (HSPs) and protects against caerulein pancreatitis. Here, we …

Molecular insights into connective tissue growth factor action in rat pancreatic stellate cells

A Karger, B Fitzner, P Brock, G Sparmann, J Emmrich… - Cellular signalling, 2008 - Elsevier
Pancreatic fibrosis, a key feature of chronic pancreatitis and pancreatic cancer, is mediated
by activated pancreatic stellate cells (PSC). Connective tissue growth factor (CTGF) has …