User profiles for "author:Frank Uhlmann"

Frank Uhlmann

The Francis Crick Institute
Verified email at crick.ac.uk
Cited by 16813

SMC complexes: from DNA to chromosomes

F Uhlmann - Nature reviews Molecular cell biology, 2016 - nature.com
SMC (structural maintenance of chromosomes) complexes—which include condensin,
cohesin and the SMC5–SMC6 complex—are major components of chromosomes in all …

Splitting the chromosome: cutting the ties that bind sister chromatids

K Nasmyth, JM Peters, F Uhlmann - Science, 2000 - science.org
In eukaryotic cells, sister DNA molecules remain physically connected from their production
at S phase until their separation during anaphase. This cohesion is essential for the …

[HTML][HTML] Cdk-counteracting phosphatases unlock mitotic exit

E Queralt, F Uhlmann - Current opinion in cell biology, 2008 - Elsevier
Entry into mitosis of the eukaryotic cell cycle is driven by rising cyclin-dependent kinase
(Cdk) activity. During exit from mitosis, Cdk activity must again decline. Cdk downregulation …

Sister-chromatid separation at anaphase onset is promoted by cleavage of the cohesin subunit Scc1

F Uhlmann, F Lottspeich, K Nasmyth - Nature, 1999 - nature.com
Cohesion between sister chromatids is established during DNA replication and depends on
a multiprotein complex called cohesin. Attachment of sister kinetochores to the mitotic …

[HTML][HTML] Cleavage of cohesin by the CD clan protease separin triggers anaphase in yeast

F Uhlmann, D Wernic, MA Poupart, EV Koonin… - Cell, 2000 - cell.com
In eukaryotic cells, replicated DNA strands remain physically connected until their
segregation to opposite poles of the cell during anaphase. This" sister chromatid cohesion" …

Yeast cohesin complex requires a conserved protein, Eco1p (Ctf7), to establish cohesion between sister chromatids during DNA replication

A Tóth, R Ciosk, F Uhlmann, M Galova… - Genes & …, 1999 - genesdev.cshlp.org
Sister chromatid cohesion is crucial for chromosome segregation during mitosis. Loss of
cohesion very possibly triggers sister separation at the metaphase→ anaphase transition …

Cohesin relocation from sites of chromosomal loading to places of convergent transcription

A Lengronne, Y Katou, S Mori, S Yokobayashi… - Nature, 2004 - nature.com
Sister chromatids, the products of eukaryotic DNA replication, are held together by the
chromosomal cohesin complex after their synthesis. This allows the spindle in mitosis to …

[PDF][PDF] Cohesion between sister chromatids must be established during DNA replication

F Uhlmann, K Nasmyth - Current Biology, 1998 - cell.com
Background: Cohesion between sister chromatids, which opposes the splitting force exerted
by the mitotic spindle during metaphase, is essential for their segregation to opposite poles …

Eco1-dependent cohesin acetylation during establishment of sister chromatid cohesion

TR Ben-Shahar, S Heeger, C Lehane, P East, H Flynn… - Science, 2008 - science.org
Replicated chromosomes are held together by the chromosomal cohesin complex from the
time of their synthesis in S phase onward. This requires the replication fork–associated …

[HTML][HTML] Disjunction of homologous chromosomes in meiosis I depends on proteolytic cleavage of the meiotic cohesin Rec8 by separin

SBC Buonomo, RK Clyne, J Fuchs, J Loidl, F Uhlmann… - Cell, 2000 - cell.com
It has been proposed but never proven that cohesion between sister chromatids distal to
chiasmata is responsible for holding homologous chromosomes together while spindles …