User profiles for "author:Frank Uhlmann"
Frank UhlmannThe Francis Crick Institute Verified email at crick.ac.uk Cited by 16813 |
SMC complexes: from DNA to chromosomes
F Uhlmann - Nature reviews Molecular cell biology, 2016 - nature.com
SMC (structural maintenance of chromosomes) complexes—which include condensin,
cohesin and the SMC5–SMC6 complex—are major components of chromosomes in all …
cohesin and the SMC5–SMC6 complex—are major components of chromosomes in all …
Splitting the chromosome: cutting the ties that bind sister chromatids
In eukaryotic cells, sister DNA molecules remain physically connected from their production
at S phase until their separation during anaphase. This cohesion is essential for the …
at S phase until their separation during anaphase. This cohesion is essential for the …
[HTML][HTML] Cdk-counteracting phosphatases unlock mitotic exit
Entry into mitosis of the eukaryotic cell cycle is driven by rising cyclin-dependent kinase
(Cdk) activity. During exit from mitosis, Cdk activity must again decline. Cdk downregulation …
(Cdk) activity. During exit from mitosis, Cdk activity must again decline. Cdk downregulation …
Sister-chromatid separation at anaphase onset is promoted by cleavage of the cohesin subunit Scc1
F Uhlmann, F Lottspeich, K Nasmyth - Nature, 1999 - nature.com
Cohesion between sister chromatids is established during DNA replication and depends on
a multiprotein complex called cohesin. Attachment of sister kinetochores to the mitotic …
a multiprotein complex called cohesin. Attachment of sister kinetochores to the mitotic …
[HTML][HTML] Cleavage of cohesin by the CD clan protease separin triggers anaphase in yeast
In eukaryotic cells, replicated DNA strands remain physically connected until their
segregation to opposite poles of the cell during anaphase. This" sister chromatid cohesion" …
segregation to opposite poles of the cell during anaphase. This" sister chromatid cohesion" …
Yeast cohesin complex requires a conserved protein, Eco1p (Ctf7), to establish cohesion between sister chromatids during DNA replication
Sister chromatid cohesion is crucial for chromosome segregation during mitosis. Loss of
cohesion very possibly triggers sister separation at the metaphase→ anaphase transition …
cohesion very possibly triggers sister separation at the metaphase→ anaphase transition …
Cohesin relocation from sites of chromosomal loading to places of convergent transcription
A Lengronne, Y Katou, S Mori, S Yokobayashi… - Nature, 2004 - nature.com
Sister chromatids, the products of eukaryotic DNA replication, are held together by the
chromosomal cohesin complex after their synthesis. This allows the spindle in mitosis to …
chromosomal cohesin complex after their synthesis. This allows the spindle in mitosis to …
[PDF][PDF] Cohesion between sister chromatids must be established during DNA replication
F Uhlmann, K Nasmyth - Current Biology, 1998 - cell.com
Background: Cohesion between sister chromatids, which opposes the splitting force exerted
by the mitotic spindle during metaphase, is essential for their segregation to opposite poles …
by the mitotic spindle during metaphase, is essential for their segregation to opposite poles …
Eco1-dependent cohesin acetylation during establishment of sister chromatid cohesion
TR Ben-Shahar, S Heeger, C Lehane, P East, H Flynn… - Science, 2008 - science.org
Replicated chromosomes are held together by the chromosomal cohesin complex from the
time of their synthesis in S phase onward. This requires the replication fork–associated …
time of their synthesis in S phase onward. This requires the replication fork–associated …
[HTML][HTML] Disjunction of homologous chromosomes in meiosis I depends on proteolytic cleavage of the meiotic cohesin Rec8 by separin
SBC Buonomo, RK Clyne, J Fuchs, J Loidl, F Uhlmann… - Cell, 2000 - cell.com
It has been proposed but never proven that cohesion between sister chromatids distal to
chiasmata is responsible for holding homologous chromosomes together while spindles …
chiasmata is responsible for holding homologous chromosomes together while spindles …