Increases in eosinophil numbers are associated with infection and allergic diseases,
including asthma, but there is also evidence that eosinophils contribute to homeostatic …

Background Phenotyping asthma according to airway inflammation allows identification of
responders to targeted therapy. Induced sputum is technically demanding. We aimed to …

Background It has been claimed that exhaled nitric oxide (FeNO) could be regarded as a
surrogate marker for sputum eosinophil count in patients with asthma. However, the FeNO …

Rationale: Analysis of exhaled breath for asthma phenotyping using endogenously
generated volatile organic compounds (VOCs) offers the possibility of noninvasive diagnosis …

Background Longitudinal trials have suggested that asthma control may be influenced by
fluctuations in eosinophilic inflammation. This association has however never been …

Objectives The impact of inhaled corticosteroids (ICS) on eosinophilic inflammation in
asthma is well established, but their effect in a real-life setting has not been extensively …

Bronchial thermoplasty (BT) is to date the only therapy that provides a lasting reduction in
airway wall remodelling. However, the mechanism of action of BT is not well understood …

Inflammation associated oxidative stress leads to peroxidation of polyunsaturated fatty acids
thereby generating volatile organic compounds (VOCs). The integrative analysis of the total …

Background Severe asthma (SA) may require frequent courses or chronic use of oral
corticosteroids (OCS), inducing many known side effects and complications. Therefore, it is …

The concept of asthma inflammatory phenotypes has proved to be important in predicting
response to inhaled corticosteroids. Induced sputum, which has been pivotal in the …