Event-free survival (EFS) at 5 years in pediatric acute lymphoblastic leukemia (ALL) is>
80%. Outcome in adult ALL is still unsatisfactory, which is due to less cumulative dosing of …

The prognosis of central nervous system (CNS) relapse of systemic non‐Hodgkin lymphoma
is poor with 1‐year survival historically at 0% to 20%. Aiming to improve these results, we …

Effective dose is an important quantity in relation to assessment of radiation risk. Organ and
effective doses to paediatric patients undergoing diagnostic and therapeutic heart …

Background: It has been shown that treatment with a long acting β2 agonist in addition to a
glucocorticoid is beneficial in the treatment of asthma. In asthma inflammatory cells …

The expression of the adhesion molecules intercellular adhesion molecule-1 (ICAM-1) and
more specifically vascular adhesion molecule-1 (VCAM-1) on lung fibroblasts may be …

Asthma is a disease characterized by inflammation, airway remodelling, variable airway
obstruction and hyper-responsiveness. Usually, asthmatic patients are sensitized to one or …

In a prospective multicenter phase II study, we evaluated the effect of three courses of
vincristine, doxorubicin and dexamethasone followed by high-dose melphalan and …

The glucocorticoid budesonide and the long-acting beta2-adrenoceptor agonist formoterol
are used in asthma therapy for their anti-inflammatory and bronchodilating effects …

The nonspecific phosphodiesterase inhibitor theophylline, widely used in asthma therapy,
may cause a decrease in inflammatory responses of airways. In asthma, eosinophils migrate …

Eosinophilic airway infiltration is a central feature in asthma. Eosinophils recovered from
bronchoalveolar fluid show an activated phenotype, eg, increased CD11b and decreased L …