Congenital hyperinsulinism (CHI or HI) is a condition leading to recurrent hypoglycemia due
to an inappropriate insulin secretion by the pancreatic islet β cells. HI has two main …

A collaborative study, supported by the Biomed2 Programme of the European Community,
was initiated to optimise the aetiological diagnosis in genetic or gonadal males with intersex …

Frasier syndrome (FS) is a rare disease defined by male pseudo-hermaphroditism and
progressive glomerulopathy1–3. Patients present with normal female external genitalia …

MATERIALS AND METHODS Comparative sequence analysis To obtain the full length
mouse sequence, we directly sequenced by primer walking8 the BAC 13L19 (RP23 Mouse …

In this review, we describe recent results concerning the genetics of sex determination in
mammals. Particularly, we developed the study of the FOXL2 gene and its implication in …

Fetal male sexual differentiation is driven by two testicular hormones: testosterone
(synthesized by interstitial Leydig cells) and antimüllerian hormone (AMH; produced by …

Sex cord stromal tumors are gonadal neoplasms containing Sertoli, granulosa, Leydig, or
thecal cells, which originate from cells derived from either the sex cords (Sertoli and …

Background Langerhans cell histiocytosis (LCH) is a rare clonal granulomatous disease that
affects mainly children. LCH can involve various tissues such as bone, skin, lung, bone …

Hyperinsulinism (HI) of infancy is a neuroendocrine disease secondary to either focal
adenomatous hyperplasia or a diffuse abnormality of insulin secretion of the pancreas. HI …

Neisseria meningitidis is a commensal bacterium of the human nasopharynx. Occasionally,
this bacterium reaches the bloodstream and causes meningitis after crossing the blood …