Carbon monoxide (CO), one of the products of heme oxygenase action on heme, prevents
arteriosclerotic lesions that occur following aorta transplantation; pre-exposure to 250 parts …

CD39, or vascular adenosine triphosphate diphosphohydrolase, has been considered an
important inhibitor of platelet activation. Unexpectedly, cd39-deficient mice had prolonged …

Mouse-to-rat cardiac transplants survive long term after transient complement depletion by
cobra venom factor and T cell immunosuppression by cyclosporin A. Expression of heme …

Rationale: Adaptive immune responses are present in patients with chronic obstructive
pulmonary disease (COPD), and it has been postulated that these processes could be …

One classical feature of cancer cells is their metabolic acquisition of a highly glycolytic
phenotype. Carbon monoxide (CO), one of the products of the cytoprotective molecule heme …

Background—Bilirubin, a natural product of heme catabolism by heme oxygenases, was
considered a toxic waste product until 1987, when its antioxidant potential was recognized …

BACKGROUND & AIMS: Adenosine mediates immune suppression and is generated by the
ectonucleotidases CD39 (ENTPD1) and CD73 that are expressed on vascular endothelial …

CD39/ENTPD1 hydrolyzes proinflammatory nucleotides to generate adenosine. As
purinergic mediators have been implicated in intestinal inflammation, we hypothesized that …

Mesenchymal stem cells (MSCs) are multipotent progenitor cells with the ability to
differentiate into multiple mesoderm lineages in the course of normal tissue homeostasis or …

Controlled activation is a critical component in prodrug development. Here we report a
concentration-sensitive platform approach for bioorthogonal prodrug activation by taking …