User profiles for "author:Erik Melén"

Erik Melén

Department of Clinical Science and Education Södersjukhuset, Karolinska Institutet
Verified email at ki.se
Cited by 32441

Allergic Rhinitis and its Impact on Asthma (ARIA): achievements in 10 years and future needs

J Bousquet, HJ Schünemann, B Samolinski… - Journal of Allergy and …, 2012 - Elsevier
Allergic rhinitis (AR) and asthma represent global health problems for all age groups.
Asthma and rhinitis frequently coexist in the same subjects. Allergic Rhinitis and its Impact …

[HTML][HTML] Allergic rhinitis

J Bousquet, JM Anto, C Bachert, I Baiardini… - Nature Reviews …, 2020 - nature.com
Allergic rhinitis (AR) is caused by immunoglobulin E (IgE)-mediated reactions to inhaled
allergens and is one of the most common chronic conditions globally. AR often co-occurs …

Next-generation Allergic Rhinitis and Its Impact on Asthma (ARIA) guidelines for allergic rhinitis based on Grading of Recommendations Assessment, Development …

J Bousquet, HJ Schünemann, A Togias… - Journal of Allergy and …, 2020 - Elsevier
The selection of pharmacotherapy for patients with allergic rhinitis aims to control the
disease and depends on many factors. Grading of Recommendations Assessment …

[PDF][PDF] DNA methylation in newborns and maternal smoking in pregnancy: genome-wide consortium meta-analysis

BR Joubert, JF Felix, P Yousefi, KM Bakulski… - The American Journal of …, 2016 - cell.com
Epigenetic modifications, including DNA methylation, represent a potential mechanism for
environmental impacts on human disease. Maternal smoking in pregnancy remains an …

Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis

JS Ried, J Li, XB Zuo, XD Zheng, XY Yin, LD Sun… - Nature …, 2015 - nature.com
Genetic association studies have identified 21 loci associated with atopic dermatitis risk
predominantly in populations of European ancestry. To identify further susceptibility loci for …

Impact of maternal body mass index and gestational weight gain on pregnancy complications: an individual participant data meta‐analysis of European, North …

S Santos, E Voerman, P Amiano… - … Journal of Obstetrics …, 2019 - Wiley Online Library
Objective To assess the separate and combined associations of maternal pre‐pregnancy
body mass index (BMI) and gestational weight gain with the risks of pregnancy …

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

F Demenais, P Margaritte-Jeannin, KC Barnes… - Nature …, 2018 - nature.com
We examined common variation in asthma risk by conducting a meta-analysis of worldwide
asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of …

[HTML][HTML] MMP12, Lung Function, and COPD in High-Risk Populations

GM Hunninghake, MH Cho, Y Tesfaigzi… - … England Journal of …, 2009 - Mass Medical Soc
Background Genetic variants influencing lung function in children and adults may ultimately
lead to the development of chronic obstructive pulmonary disease (COPD), particularly in …

[HTML][HTML] Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in …

LV Wain, N Shrine, S Miller, VE Jackson… - The Lancet …, 2015 - thelancet.com
Background Understanding the genetic basis of airflow obstruction and smoking behaviour
is key to determining the pathophysiology of chronic obstructive pulmonary disease (COPD) …

Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis

L Paternoster, M Standl, CM Chen, A Ramasamy… - Nature …, 2012 - nature.com
Atopic dermatitis (AD) is a commonly occurring chronic skin disease with high heritability.
Apart from filaggrin (FLG), the genes influencing atopic dermatitis are largely unknown. We …