A range of low molecular weight chemicals have been developed to antagonise the eotaxin
receptor, cysteine-cysteine chemokine receptor-3 (CCR3), with the aim of selectively …

The use of noninvasive methods of monitoring airway inflammation, such as exhaled nitric
oxide (eNO) and induced sputum, has been shown to improve asthma monitoring and …

Rationale: Neutralization of tumor necrosis factor-α (TNF-α) is an effective antiinflammatory
therapy for several chronic inflammatory diseases. Methods and Objectives: We undertook a …

The inducible isoenzyme of nitric oxide synthase (iNOS) generates nitric oxide (NO) in
inflammatory diseases such as asthma. The prodrug L‐N6‐(1‐iminoethyl) lysine 5‐tetrazole …

Despite having been recognized for a long time as a cheap and effective therapy for the
treatment of asthma and chronic obstructive pulmonary disease (COPD), theophylline is …

Bronchodilators are the mainstay of therapy for patients with established chronic obstructive
pulmonary disease (COPD) but, at present, the majority of patients use short-acting agents …

Background Cytokines and chemokines produced by allergen‐reactive T‐helper type 2
(Th2) cells may be pivotal to the pathophysiology of allergic disorders. Objective This study …

Introduction Inhaled anticholinergic drugs are effective bronchodilators in the treatment of
COPD, and tiotropium bromide has recently been introduced as a once-daily bronchodilator …

Background Ciclesonide is a novel inhaled corticosteroid for the treatment of asthma, and it
is important to measure the onset of effect of this therapy on airway hyperresponsiveness …

Background: Nasal lavage is a noninvasive method of obtaining inflammatory exudates
following nasal allergen challenge (NAC), and permits cells and released mediators to be …