Background: Chronic obstructive pulmonary disease (COPD) is a leading cause of
morbidity, mortality, and resource use worldwide. The goal of this Official American Thoracic …

Regular smoking of marijuana by itself causes visible and microscopic injury to the large
airways that is consistently associated with an increased likelihood of symptoms of chronic …

Bronchodilators form the foundation of symptomatic treatment of COPD. Several long-acting
bronchodilators are now available for use in COPD, but publications of large-scale studies of …

Objective.—To determine whether a program incorporating smoking intervention and use of
an inhaled bronchodilator can slow the rate of decline in forced expiratory volume in 1 …

Background We conducted a double-blind, randomized, placebo-controlled trial to
determine the effects of oral cyclophosphamide on lung function and health-related …

Background Previous studies showing that tiotropium improves multiple end points in
patients with chronic obstructive pulmonary disease (COPD) led us to examine the long-term …

Background 12 months of oral cyclophosphamide has been shown to alter the progression
of scleroderma-related interstitial lung disease when compared with placebo. However …

Background Currently, the diagnosis of chronic obstructive pulmonary disease (COPD)
requires a ratio of forced expiratory volume in 1 second (FEV1) to forced vital capacity (FVC) …

Rationale: The Scleroderma Lung Study enrolled 158 patients with scleroderma-related
interstitial lung disease in a placebo-controlled trial of oral cyclophosphamide (CYC) …

Background The beneficial effects of pharmacotherapy for chronic obstructive pulmonary
disease (COPD) are well established. However, there are few data for treatment in the early …