Objectives To assess the overall effect of vitamin D supplementation on risk of acute
respiratory tract infection, and to identify factors modifying this effect. Design Systematic …

Background A 2017 meta-analysis of data from 25 randomised controlled trials (RCTs) of
vitamin D supplementation for the prevention of acute respiratory infections (ARIs) revealed …

Background A previous aggregate data meta-analysis of randomised controlled trials
showed that vitamin D supplementation reduces the rate of asthma exacerbations requiring …

Background: Randomised controlled trials (RCTs) exploring the potential of vitamin D to
prevent acute respiratory infections have yielded mixed results. Individual participant data …

Background Patients with chronic obstructive pulmonary disease (COPD) often have vitamin
D deficiency, which is associated with increased susceptibility to upper respiratory infection …

Vitamin D metabolites enhance immunity to a wide range of respiratory pathogens in vitro.
Numerous observational studies have investigated whether vitamin D deficiency is a risk …

Objective To determine the effect of population level implementation of a test-and-treat
approach to correction of suboptimal vitamin D status (25-hydroxyvitamin D (25 (OH) D)< 75 …

Background Randomised controlled trials (RCTs) of vitamin D to prevent COPD
exacerbations have yielded conflicting results. Individual participant data meta-analysis …

Rationale Asthma exacerbations are commonly precipitated by viral upper respiratory
infections (URIs). Vitamin D insufficiency associates with susceptibility to URI in patients with …

Polymorphisms in genes encoding proteins involved in vitamin D metabolism and transport
are recognised to influence vitamin D status. Syntheses of genetic association studies …