The DISC locus in psychiatric illness
JE Chubb, NJ Bradshaw, DC Soares, DJ Porteous… - Molecular …, 2008 - nature.com
The DISC locus is located at the breakpoint of a balanced t (1; 11) chromosomal
translocation in a large and unique Scottish family. This translocation segregates in a highly …
translocation in a large and unique Scottish family. This translocation segregates in a highly …
[HTML][HTML] The Lothian Birth Cohort 1936: a study to examine influences on cognitive ageing from age 11 to age 70 and beyond
Background Cognitive ageing is a major burden for society and a major influence in
lowering people's independence and quality of life. It is the most feared aspect of ageing …
lowering people's independence and quality of life. It is the most feared aspect of ageing …
CpG-free plasmids confer reduced inflammation and sustained pulmonary gene expression
SC Hyde, IA Pringle, S Abdullah, AE Lawton… - Nature …, 2008 - nature.com
Pulmonary delivery of plasmid DNA (pDNA)/cationic liposome complexes is associated with
an acute unmethylated CG dinucleotide (CpG)-mediated inflammatory response and brief …
an acute unmethylated CG dinucleotide (CpG)-mediated inflammatory response and brief …
[HTML][HTML] Genetic mechanisms of critical illness in COVID-19
Host-mediated lung inflammation is present, and drives mortality, in the critical illness
caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with …
caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with …
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals
Here we conducted a large-scale genetic association analysis of educational attainment in a
sample of approximately 1.1 million individuals and identify 1,271 independent genome …
sample of approximately 1.1 million individuals and identify 1,271 independent genome …
Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions
Major depression is a debilitating psychiatric illness that is typically associated with low
mood and anhedonia. Depression has a heritable component that has remained difficult to …
mood and anhedonia. Depression has a heritable component that has remained difficult to …
[HTML][HTML] Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals
We conduct a genome-wide association study (GWAS) of educational attainment (EA) in a
sample of~ 3 million individuals and identify 3,952 approximately uncorrelated genome …
sample of~ 3 million individuals and identify 3,952 approximately uncorrelated genome …
Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection
AF Pardiñas, P Holmans, AJ Pocklington… - Nature …, 2018 - nature.com
Schizophrenia is a debilitating psychiatric condition often associated with poor quality of life
and decreased life expectancy. Lack of progress in improving treatment outcomes has been …
and decreased life expectancy. Lack of progress in improving treatment outcomes has been …
Genome-wide association study identifies 74 loci associated with educational attainment
Educational attainment is strongly influenced by social and other environmental factors, but
genetic factors are estimated to account for at least 20% of the variation across individuals 1 …
genetic factors are estimated to account for at least 20% of the variation across individuals 1 …
Disruption of two novel genes by a translocation co-segregating with schizophrenia
JK Millar, JC Wilson-Annan, S Anderson… - Human molecular …, 2000 - academic.oup.com
Abstract A balanced (1; 11)(q42. 1; q14. 3) translocation segregates with schizophrenia and
related psychiatric disorders in a large Scottish family (maximum LOD= 6.0). We hypothesize …
related psychiatric disorders in a large Scottish family (maximum LOD= 6.0). We hypothesize …