The gut microbiota plays an important role in cardio-metabolic diseases with diet being
among the strongest modulators of gut microbiota composition and function. Resistant …

Cardiometabolic diseases have become a leading cause of morbidity and mortality globally.
They have been tightly linked to microbiome taxonomic and functional composition, with diet …

Reports of long-lasting coronavirus disease 2019 (COVID-19) symptoms, the so-called 'long
COVID', are rising but little is known about prevalence, risk factors or whether it is possible to …

Age is the strongest risk factor for many diseases including neurodegenerative disorders,
coronary heart disease, type 2 diabetes and cancer. Due to increasing life expectancy and …

Summary Background The Pfizer-BioNTech (BNT162b2) and the Oxford-AstraZeneca
(ChAdOx1 nCoV-19) COVID-19 vaccines have shown excellent safety and efficacy in phase …

Abstract A total of 2,618,862 participants reported their potential symptoms of COVID-19 on
a smartphone-based app. Among the 18,401 who had undergone a SARS-CoV-2 test, the …

Summary Background The SARS-CoV-2 variant of concern, omicron, appears to be less
severe than delta. We aim to quantify the differences in symptom prevalence, risk of hospital …

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic
outcomes, independent of overall adiposity. To increase our understanding of the genetic …

Genome-wide association scans with high-throughput metabolic profiling provide
unprecedented insights into how genetic variation influences metabolism and complex …

High blood pressure is a highly heritable and modifiable risk factor for cardiovascular
disease. We report the largest genetic association study of blood pressure traits (systolic …