Mass spectrometry (MS) is the most comprehensive and versatile tool in large-scale
proteomics. In this review, we dissect the overall framework of the MS experiment into its key …

Chronic obstructive pulmonary disease (COPD) is a highly prevalent condition worldwide
and is associated with significant mortality. This paper gives an overview of the relevant …

The challenge of understanding the widespread biological roles of animal microRNAs
(miRNAs) has prompted the development of genetic and functional genomics technologies …

Structure-specific endonucleases resolve DNA secondary structures generated during DNA
repair and recombination. The yeast 5′ flap endonuclease Slx1-Slx4 has received …

The English End of Life Care Strategy promises that all patients with advanced, life limiting
illness will have the opportunity to participate in Advance Care Planning (ACP). For patients …

Tumour suppressor genes encode a broad class of molecules whose mutational attenuation
contributes to malignant progression. In the canonical situation, the tumour suppressor is …

Shotgun proteomics typically uses multidimensional LC/MS/MS analysis of enzymatically
digested proteins, where strong cation-exchange (SCX) and reversed-phase (RP) …

Prognosis in COPD is poor and many patients perceive shortcomings in the education they
receive about aspects of their condition. This study explores the experiences of patients with …

Recent studies suggest that superoxide dismutase 1 (SOD1)-linked amyotrophic lateral
sclerosis results from destabilization and misfolding of mutant forms of this abundant …

To cite this article: Beghé B, Hall IP, Parker SG, Moffatt MF, Wardlaw A, Connolly MJ, Fabbri
LM, Ruse C, Sayers I. Polymorphisms in IL13 pathway genes in asthma and chronic …