Influence of cigarette smoking on inhaled corticosteroid treatment in mild asthma
GW Chalmers, KJ Macleod, SA Little, LJ Thomson… - Thorax, 2002 - thorax.bmj.com
Background: Although inhaled corticosteroids have an established role in the treatment of
asthma, studies have tended to concentrate on non-smokers and little is known about the …
asthma, studies have tended to concentrate on non-smokers and little is known about the …
Effects of smoking cessation on lung function and airway inflammation in smokers with asthma
R Chaudhuri, E Livingston, AD McMahon… - American journal of …, 2006 - atsjournals.org
Rationale: Active smoking in asthma is associated with worsening of symptoms, accelerated
decline in lung function, and impaired response to corticosteroids. Objectives: To examine …
decline in lung function, and impaired response to corticosteroids. Objectives: To examine …
Inhibition of FcεRI-mediated mast cell responses by ES-62, a product of parasitic filarial nematodes
AJ Melendez, MM Harnett, PN Pushparaj, WSF Wong… - Nature medicine, 2007 - nature.com
Atopic allergy is characterized by an increase in IgE antibodies that signal through the high-
affinity Fcε receptor (FcεRI) to induce the release of inflammatory mediators from mast cells …
affinity Fcε receptor (FcεRI) to induce the release of inflammatory mediators from mast cells …
High resolution computed tomographic assessment of airway wall thickness in chronic asthma: reproducibility and relationship with lung function and severity
SA Little, MW Sproule, MD Cowan, KJ Macleod… - Thorax, 2002 - thorax.bmj.com
Background: In some patients chronic asthma results in irreversible airflow obstruction. High
resolution computed tomography (HRCT) has been advocated for assessing the structural …
resolution computed tomography (HRCT) has been advocated for assessing the structural …
Effect of inhaled corticosteroids on symptom severity and sputum mediator levels in chronic persistent cough
R Chaudhuri, AD McMahon, LJ Thomson… - Journal of allergy and …, 2004 - Elsevier
BACKGROUND: Chronic cough often lasts for more than 1 year and is associated with
airway inflammation. The effect of inhaled corticosteroids on symptom severity and …
airway inflammation. The effect of inhaled corticosteroids on symptom severity and …
Short and long-term effects of cigarette smoking independently influence exhaled nitric oxide concentration in asthma
CP McSharry, IC McKay, R Chaudhuri… - Journal of Allergy and …, 2005 - Elsevier
BACKGROUND: The fractional concentration of nitric oxide in exhaled breath (FeNO) is
elevated in asthma. FeNO measurement has been proposed as a noninvasive index of …
elevated in asthma. FeNO measurement has been proposed as a noninvasive index of …
Systemic sensitivity to corticosteroids in smokers with asthma
E Livingston, R Chaudhuri… - European respiratory …, 2007 - Eur Respiratory Soc
Cigarette smokers with asthma are insensitive to the therapeutic effects of corticosteroids. It
is not known whether this insensitivity to corticosteroids in smokers affects tissue sites …
is not known whether this insensitivity to corticosteroids in smokers affects tissue sites …
Comparison of the inhibitory effect of propofol, thiopentone and midazolam on neutrophil polarization in vitro in the presence or absence of human serum albumin
NG O'DONNELL, CP McSharry, PC Wilkinson… - British journal of …, 1992 - Elsevier
Anaesthetic agents inhibit some aspects of immune function and this may be clinically
important when prolonged infusions are used in an intensive care unit. We have studied the …
important when prolonged infusions are used in an intensive care unit. We have studied the …
Induction of protective and mucosal immunity against diphtheria by a immune stimulating complex (ISCOMS) based vaccine
A Aguila, AM Donachie, M Peyre, CP McSharry… - Vaccine, 2006 - Elsevier
There is increasing concern over the efficacy of existing vaccines for diphtheria and there is
interest in the development of a mucosally active formulation which might improve local …
interest in the development of a mucosally active formulation which might improve local …
Serum and sputum neurotrophin levels in chronic persistent cough
R Chaudhuri, AD McMahon… - Clinical & …, 2005 - Wiley Online Library
Summary Background Neurotrophins (NTs) are a family of growth factors, including nerve
growth factor (NGF), brain‐derived neurotrophic factor (BDNF) and neurotrophin3 (NT‐3) …
growth factor (NGF), brain‐derived neurotrophic factor (BDNF) and neurotrophin3 (NT‐3) …