Malignant mesothelioma is an aggressive tumor of serosal surfaces, such as the pleura and
the peritoneum. This tumor was once rare, but its incidence is increasing worldwide …

Malignant mesothelioma is an aggressive, treatment-resistant tumour, which is increasing in
frequency throughout the world. Although the main risk factor is asbestos exposure, a virus …

This article discusses how recent data have altered the way we understand how dying
tumour cells, particularly those killed by chemotherapy, engage with antitumour immune …

Background Mesothelioma is a highly aggressive tumour for which there are no reliable
serum tumour markers. Identification of such a marker would be useful in diagnosis of …

Cross-priming is an important mechanism to activate cytotoxic T lymphocytes (CTLs) for
immune defence against viruses and tumours. Although it was discovered more than 25 …

Cross-presentation of cell-bound Ags from established, solid tumors to CD8 cells is efficient
and likely to have a role in determining host response to tumor. A number of investigators …

Cytotoxic chemotherapy is generally considered immunosuppressive, with neutropenia and
lymphopenia being common adverse side effects. In this context, we have shown previously …

A number of tumor studies have indicated a link between CD4 help and the magnitude and
persistence of CTL activity; however, the mechanisms underlying this have been largely …

Most cytotoxic drugs have gross effects on the immune system, such as neutropenia and
lymphopenia. However, their effects on tumor-specific immune responses are unknown …

Therapeutic use of IL-2 can generate antitumor immunity; however, a variety of different
mechanisms have been reported. We injected IL-2 intratumorally (it) at different stages of …