BACKGROUND AND PURPOSE: Stereotactic radiosurgery is known to control 85%–95% of
intracranial metastatic lesions during a median survival of 6–8 months. However, with the …

Rationale: The vicious cycle hypothesis of bronchiectasis argues that bacterial colonization
leads to airway inflammation and progressive lung damage. The logical extension of this …

Respiratory syncytial virus is a leading cause of lower respiratory tract illness among infants,
the elderly and immunocompromised individuals. Currently, there is no effective vaccine or …

The integrin family of heterodimeric cell-surface receptors are fundamental in cell-cell and
cell-matrix adhesion. Changes to either integrin-ligand affinity or integrin gene expression …

Introduction Vitamin-D deficiency has been linked to an increased risk of respiratory
infections. The objective of this study was to determine the frequency and clinical importance …

Lung cancer is one of the most common fatal diseases in the developed world. The disease
is rarely cured by currently available therapies, with an overall survival rate of∼ 10 …

A combination therapy approach is required to improve tumor immune infiltration and patient
response to immune checkpoint inhibitors that target negative regulatory receptors. Galectin …

Background Mannose-binding lectin (MBL) is a key component of innate immunity. MBL
deficiency is common (10–30% of the general population depending on the definition used) …

Notch is a central regulator of important cell fate decisions. Notch activation produces
diverse cellular effects suggesting the presence of context-dependent control mechanisms …

Rationale: Excessive neutrophilic airway inflammation is the central feature of
bronchiectasis, but little is known about neutrophils in bronchiectasis. Objectives: To assess …