The Th1/Th2 balance in autoimmunity
B Charlton, KJ Lafferty - Current opinion in immunology, 1995 - Elsevier
The study of autoimmune disease in the context of T-helper type 1 (Th1) and T-helper type 2
(Th2) CD4+ T-cell responses demonstrates that the relative contribution of either T-cell type …
(Th2) CD4+ T-cell responses demonstrates that the relative contribution of either T-cell type …
[HTML][HTML] The safety and efficacy of inhaled dry powder mannitol as a bronchial provocation test for airway hyperresponsiveness: a phase 3 comparison study with …
JD Brannan, SD Anderson, CP Perry… - Respiratory …, 2005 - Springer
Background Inhaled mannitol is a new bronchial provocation test (BPT) developed to
improve portability and standardisation of osmotic challenge testing. Osmotic challenge tests …
improve portability and standardisation of osmotic challenge testing. Osmotic challenge tests …
[HTML][HTML] Comparison of mannitol and methacholine to predict exercise-induced bronchoconstriction and a clinical diagnosis of asthma
SD Anderson, B Charlton, JM Weiler, S Nichols… - Respiratory …, 2009 - Springer
Background Asthma can be difficult to diagnose, but bronchial provocation with
methacholine, exercise or mannitol is helpful when used to identify bronchial …
methacholine, exercise or mannitol is helpful when used to identify bronchial …
Inhaled mannitol for non-cystic fibrosis bronchiectasis: a randomised, controlled trial
D Bilton, G Tino, AF Barker, DC Chambers, A De Soyza… - Thorax, 2014 - thorax.bmj.com
Rationale Bronchiectasis is characterised by excessive production of mucus and pulmonary
exacerbations. Inhaled osmotic agents may enhance mucociliary clearance, but few long …
exacerbations. Inhaled osmotic agents may enhance mucociliary clearance, but few long …
Mechanisms of transplantation tolerance
B Charlton, H Auchincloss Jr… - Annual review of …, 1994 - annualreviews.org
Mechanisms of Transplantation Tolerance Page 1 Annu. Rev. Immunol. 1994. 12:707-34
Copyright © 1994 by Annual Reviews Inc. All rights reserved MECHANISMS OF …
Copyright © 1994 by Annual Reviews Inc. All rights reserved MECHANISMS OF …
Long-term inhaled dry powder mannitol in cystic fibrosis: an international randomized study
ML Aitken, G Bellon, K De Boeck, PA Flume… - American journal of …, 2012 - atsjournals.org
Rationale: New treatment strategies are needed to improve airway clearance and reduce
the morbidity and the time burden associated with cystic fibrosis (CF). Objectives: To …
the morbidity and the time burden associated with cystic fibrosis (CF). Objectives: To …
Beta cell MHC class I is a late requirement for diabetes
EE Hamilton-Williams, SE Palmer… - Proceedings of the …, 2003 - National Acad Sciences
Type 1 diabetes occurs as a result of an autoimmune attack on the insulin-producing beta
cells. Although CD8 T cells have been implicated both early and late in this process, the …
cells. Although CD8 T cells have been implicated both early and late in this process, the …
Inhaled mannitol improves lung function in cystic fibrosis
A Jaques, E Daviskas, JA Turton, K McKay, P Cooper… - Chest, 2008 - Elsevier
Background The airways in patients with cystic fibrosis (CF) are characterized by the
accumulation of tenacious, dehydrated mucus that is a precursor for chronic infection …
accumulation of tenacious, dehydrated mucus that is a precursor for chronic infection …
Phase 3 randomized study of the efficacy and safety of inhaled dry powder mannitol for the symptomatic treatment of non-cystic fibrosis bronchiectasis
Background Inhaled dry powder mannitol enhanced mucus clearance and improved quality
of life over 2 weeks in non-cystic fibrosis bronchiectasis. This study's objective was to …
of life over 2 weeks in non-cystic fibrosis bronchiectasis. This study's objective was to …
[HTML][HTML] A first-in-class pan-lysyl oxidase inhibitor impairs stromal remodeling and enhances gemcitabine response and survival in pancreatic cancer
JL Chitty, M Yam, L Perryman, AL Parker, JN Skhinas… - Nature Cancer, 2023 - nature.com
The lysyl oxidase family represents a promising target in stromal targeting of solid tumors
due to the importance of this family in crosslinking and stabilizing fibrillar collagens and its …
due to the importance of this family in crosslinking and stabilizing fibrillar collagens and its …