[HTML][HTML] Granuloma formation in pulmonary sarcoidosis
…, RW Hendriks, M Kool, B van den Blink - Frontiers in …, 2013 - frontiersin.org
Sarcoidosis is a granulomatous disorder of unknown cause, affecting multiple organs, but
mainly the lungs. The exact order of immunological events remains obscure. Reviewing …
mainly the lungs. The exact order of immunological events remains obscure. Reviewing …
[HTML][HTML] Mode of dendritic cell activation: the decisive hand in Th2/Th17 cell differentiation. Implications in asthma severity?
H Vroman, B van den Blink, M Kool - Immunobiology, 2015 - Elsevier
Asthma is a heterogeneous chronic inflammatory disease of the airways, with reversible
airflow limitations and airway remodeling. The classification of asthma phenotypes was …
airflow limitations and airway remodeling. The classification of asthma phenotypes was …
Inhibition of stress-activated MAP kinases induces clinical improvement in moderate to severe Crohn's disease
D Hommes, B Van Den Blink, T Plasse, J Bartelsman… - Gastroenterology, 2002 - Elsevier
BACKGROUND & AIMS:: We investigated if inhibition of mitogen-activated protein kinases
(MAPKs) was beneficial in Crohn's disease. METHODS:: Inhibition of JNK and p38 MAPK …
(MAPKs) was beneficial in Crohn's disease. METHODS:: Inhibition of JNK and p38 MAPK …
Endosonography vs conventional bronchoscopy for the diagnosis of sarcoidosis: the GRANULOMA randomized clinical trial
…, KG Tournoy, M Claussen, B van den Blink… - Jama, 2013 - jamanetwork.com
Importance Tissue verification of noncaseating granulomas is recommended for the
diagnosis of sarcoidosis. Bronchoscopy with transbronchial lung biopsies, the current …
diagnosis of sarcoidosis. Bronchoscopy with transbronchial lung biopsies, the current …
IFN-γ–producing T-helper 17.1 cells are increased in sarcoidosis and are more prevalent than T-helper type 1 cells
…, BS Benn, RW Hendriks, B van den Blink… - American journal of …, 2016 - atsjournals.org
Rationale: Pulmonary sarcoidosis is classically defined by T-helper (Th) cell type 1
inflammation (eg, IFN-γ production by CD4+ effector T cells). Recently, IL-17A–secreting …
inflammation (eg, IFN-γ production by CD4+ effector T cells). Recently, IL-17A–secreting …
Anti-inflammatory effects of a p38 mitogen-activated protein kinase inhibitor during human endotoxemia
J Branger, B van den Blink, S Weijer… - The journal of …, 2002 - journals.aai.org
The p38 mitogen-activated protein kinase (MAPK) participates in intracellular signaling
cascades resulting in inflammatory responses. Therefore, inhibition of the p38 MAPK …
cascades resulting in inflammatory responses. Therefore, inhibition of the p38 MAPK …
Effect of recombinant human pentraxin 2 vs placebo on change in forced vital capacity in patients with idiopathic pulmonary fibrosis: a randomized clinical trial
G Raghu, B Van Den Blink, MJ Hamblin, AW Brown… - Jama, 2018 - jamanetwork.com
Importance Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease with
poor prognosis. Approved therapies do not halt disease progression. Objective To …
poor prognosis. Approved therapies do not halt disease progression. Objective To …
Ziritaxestat, a novel autotaxin inhibitor, and lung function in idiopathic pulmonary fibrosis: the ISABELA 1 and 2 randomized clinical trials
…, B Penninckx, MJ Randall, B Van Den Blink… - Jama, 2023 - jamanetwork.com
Importance There is a major need for effective, well-tolerated treatments for idiopathic
pulmonary fibrosis (IPF). Objective To assess the efficacy and safety of the autotaxin inhibitor …
pulmonary fibrosis (IPF). Objective To assess the efficacy and safety of the autotaxin inhibitor …
Increased IL-17A expression in granulomas and in circulating memory T cells in sarcoidosis
…, MS Paats, IM Bergen, B van den Blink… - …, 2012 - academic.oup.com
Objective. Sarcoidosis is a systemic inflammatory disorder characterized by granulomas.
Although the aetiology is unknown, sarcoidosis is thought to be mediated by Th1 …
Although the aetiology is unknown, sarcoidosis is thought to be mediated by Th1 …
Serum biomarkers in idiopathic pulmonary fibrosis
B Van den Blink, MS Wijsenbeek… - Pulmonary pharmacology …, 2010 - Elsevier
Within the group of Idiopathic Interstitial Pneumonias (IIPs), above all Idiopathic Pulmonary
Fibrosis (IPF) poses a considerable diagnostic and therapeutic problem. Although genetic …
Fibrosis (IPF) poses a considerable diagnostic and therapeutic problem. Although genetic …