Vagal afferent innervation of the airways in health and disease

SB Mazzone, BJ Undem - Physiological reviews, 2016 - journals.physiology.org
Vagal sensory neurons constitute the major afferent supply to the airways and lungs.
Subsets of afferents are defined by their embryological origin, molecular profile …

Immunological aspects of allergic asthma

BS Bochner, BJ Undem… - Annual review of …, 1994 - annualreviews.org
Asthma is a chronic obstructive disease of the lower airways. It is charac terized by episodic
exacerbations of at least partially reversible airflow limitation, along with bronchial …

Phosphodiesterase inhibitors: new opportunities for the treatment of asthma.

TJ Torphy, BJ Undem - Thorax, 1991 - ncbi.nlm.nih.gov
Theophylline has been a mainstay in the treatment of asthma for over 50 years. Its thera-
peutic value stems from a combination of anti-inflammatory and bronchodilator activitiesin …

Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions

BD McNeil, P Pundir, S Meeker, L Han, BJ Undem… - Nature, 2015 - nature.com
Mast cells are primary effectors in allergic reactions, and may have important roles in
disease by secreting histamine and various inflammatory and immunomodulatory …

[HTML][HTML] Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus

Q Liu, Z Tang, L Surdenikova, S Kim, KN Patel, A Kim… - Cell, 2009 - cell.com
The cellular and molecular mechanisms mediating histamine-independent itch in primary
sensory neurons are largely unknown. Itch induced by chloroquine (CQ) is a common side …

Identification of the tracheal and laryngeal afferent neurones mediating cough in anaesthetized guinea‐pigs

BJ Canning, SB Mazzone, SN Meeker… - The Journal of …, 2004 - Wiley Online Library
We have identified the tracheal and laryngeal afferent nerves regulating cough in
anaesthetized guinea‐pigs. Cough was evoked by electrical or mechanical stimulation of …

Prostaglandin-induced activation of nociceptive neurons via direct interaction with transient receptor potential A1 (TRPA1)

TE Taylor-Clark, BJ Undem, DW MacGlashan… - Molecular …, 2008 - ASPET
Inflammation contributes to pain hypersensitivity through multiple mechanisms. Among the
most well characterized of these is the sensitization of primary nociceptive neurons by …

Expression and function of the ion channel TRPA1 in vagal afferent nerves innervating mouse lungs

C Nassenstein, K Kwong, T Taylor‐Clark… - The Journal of …, 2008 - Wiley Online Library
Transient receptor potential (TRP) A1 and TRPM8 are ion channels that have been localized
to afferent nociceptive nerves. These TRP channels may be of particular relevance to …

Subtypes of vagal afferent C‐fibres in guinea‐pig lungs

BJ Undem, B Chuaychoo, MG Lee… - The Journal of …, 2004 - Wiley Online Library
An ex vivo, vagally innervated, lung preparation was used to address the hypothesis that
vagal C‐fibres comprise at least two distinct phenotypes. Histological and extracellular …

Relative contributions of TRPA1 and TRPV1 channels in the activation of vagal bronchopulmonary C‐fibres by the endogenous autacoid 4‐oxononenal

TE Taylor‐Clark, MA McAlexander… - The Journal of …, 2008 - Wiley Online Library
Transient receptor potential (TRP) A1 channels are cation channels found preferentially on
nociceptive sensory neurones, including capsaicin‐sensitive TRPV1‐expressing vagal …