Background Leprosy is an infectious disease caused by Mycobacterium leprae. As
incidence begins to decline, the characteristics of new cases shifts away from those …

Mycobacterium leprae, the causative agent of leprosy, is still actively transmitted in endemic
areas reflected by the fairly stable number of new cases detected each year. Recognizing …

Leprosy is still a considerable health threat in pockets of several low and middle income
countries worldwide where intense transmission is witnessed, and often results in …

With the emergence of multidrug resistant (MDR) bacteria, it is imperative to develop new
intervention strategies. Current antibiotics typically target pathogen rather than host-specific …

Regulatory T cells (Treg) comprise multiple subsets and are important in controlling
immunity and inflammation. However, the induction and mode of action of the various …

In this study, we used an HLA-A2 transgenic mouse model to investigate the effects of
pulmonary delivery of a new DNA plasmid encoding eight HLA-A* 0201-restricted T-cell …

The early secreted antigenic target 6-kDa protein (ESAT-6) and culture filtrate protein 10
(CFP-10) are promising antigens for reliable immunodiagnosis of tuberculosis. Both …

The incidence of genital human papillomavirus (HPV) infections is high in young, sexually
active individuals. Most infections are cleared within 1 year after infection. The targets for the …

Background User-friendly, rapid, inexpensive yet accurate TB diagnostic tools are urgently
needed at points of care in resource-limited settings. We investigated host biomarkers …

Tuberculosis (TB) is an escalating global health problem and improved vaccines against TB
are urgently needed. HLA-E restricted responses may be of interest for vaccine development …