[HTML][HTML] Human lung epithelial cell cultures for analysis of inhaled toxicants: Lessons learned and future directions

PS Hiemstra, G Grootaers, AM van der Does, CAM Krul… - Toxicology in vitro, 2018 - Elsevier
The epithelium that covers the conducting airways and alveoli is a primary target for inhaled
toxic substances, and therefore a focus in inhalation toxicology. The increasing concern …

Induction of the human cathelicidin LL-37 as a novel treatment against bacterial infections

AM van der Does, P Bergman… - Journal of leukocyte …, 2012 - academic.oup.com
Review on endogenous antimicrobial peptide induction by (phenyl) butyrate and vitamin D3
as a new anti-infective strategy. As traditional antibiotics gradually become inefficient, there …

Antimicrobial peptides and innate lung defenses: role in infectious and noninfectious lung diseases and therapeutic applications

PS Hiemstra, GD Amatngalim, AM van der Does… - Chest, 2016 - Elsevier
Respiratory infections are a major clinical problem, and treatment is increasingly
complicated by the emergence of microbial antibiotic resistance. Development of new …

[PDF][PDF] Pancreatic β-cells limit autoimmune diabetes via an immunoregulatory antimicrobial peptide expressed under the influence of the gut microbiota

J Sun, L Furio, R Mecheri, AM van der Does… - Immunity, 2015 - cell.com
Antimicrobial peptides (AMPs) expressed by epithelial and immune cells are largely
described for the defense against invading microorganisms. Recently, their …

LL-37 directs macrophage differentiation toward macrophages with a proinflammatory signature

AM van der Does, H Beekhuizen… - The journal of …, 2010 - journals.aai.org
The human cathelicidin LL-37 has broad-spectrum antimicrobial activity. It also participates
at the interface of innate and adaptive immunity by chemoattracting immune effector cells …

[HTML][HTML] Prolonged activation of nasal immune cell populations and development of tissue-resident SARS-CoV-2-specific CD8+ T cell responses following COVID-19

AHE Roukens, CR Pothast, M König, W Huisman… - Nature …, 2022 - nature.com
Systemic immune cell dynamics during coronavirus disease 2019 (COVID-19) are
extensively documented, but these are less well studied in the (upper) respiratory tract …

Neutrophil-derived cathelicidin promotes adhesion of classical monocytes

S Wantha, JE Alard, RTA Megens… - Circulation …, 2013 - Am Heart Assoc
Rationale: The leukocyte response in acute inflammation is characterized by an initial
recruitment of neutrophils preceding a second wave of monocytes. Neutrophil-derived …

Antimicrobial peptide LL-37 promotes bacterial phagocytosis by human macrophages

M Wan, AM van der Does, X Tang… - Journal of leukocyte …, 2014 - academic.oup.com
Abstract LL-37/hCAP-18 is the only human member of the cathelicidin family and plays an
important role in killing various pathogens, as well as in immune modulation. In this study …

[HTML][HTML] Maggot excretions/secretions inhibit multiple neutrophil pro-inflammatory responses

MJA van der Plas, AM van der Does, M Baldry… - Microbes and …, 2007 - Elsevier
There is renewed interest in the use of maggots (Lucilia sericata) to aid in healing of chronic
wounds. In such wounds neutrophils precipitate tissue damage rather than contribute to …

Organoid-based expansion of patient-derived primary alveolar type 2 cells for establishment of alveolus epithelial Lung-Chip cultures

S van Riet, A van Schadewijk… - … of Physiology-Lung …, 2022 - journals.physiology.org
Abstract Development of effective treatment strategies for lung tissue destruction as seen in
emphysema would greatly benefit from representative human in vitro models of the alveolar …