Acute skeletal muscle wasting in critical illness

ZA Puthucheary, J Rawal, M McPhail, B Connolly… - Jama, 2013 - jamanetwork.com
Importance Survivors of critical illness demonstrate skeletal muscle wasting with associated
functional impairment. Objective To perform a comprehensive prospective characterization …

Age‐related differences in the dose–response relationship of muscle protein synthesis to resistance exercise in young and old men

V Kumar, A Selby, D Rankin, R Patel… - The Journal of …, 2009 - Wiley Online Library
We investigated how myofibrillar protein synthesis (MPS) and muscle anabolic signalling
were affected by resistance exercise at 20–90% of 1 repetition maximum (1 RM) in two …

[HTML][HTML] Myofibrillar muscle protein synthesis rates subsequent to a meal in response to increasing doses of whey protein at rest and after resistance exercise

OC Witard, SR Jackman, L Breen, K Smith… - The American journal of …, 2014 - Elsevier
Background: The intake of whey, compared with casein and soy protein intakes, stimulates a
greater acute response of muscle protein synthesis (MPS) to protein ingestion in rested and …

Disassociation between the effects of amino acids and insulin on signaling, ubiquitin ligases, and protein turnover in human muscle

PL Greenhaff, LG Karagounis… - American Journal …, 2008 - journals.physiology.org
We determined the effects of intravenous infusion of amino acids (AA) at serum insulin of 5,
30, 72, and 167 mU/l on anabolic signaling, expression of ubiquitin-proteasome …

Influenza burden, prevention, and treatment in asthma‐A scoping review by the EAACI Influenza in asthma task force

J Schwarze, P Openshaw, A Jha, SR Del Giacco… - Allergy, 2018 - Wiley Online Library
To address uncertainties in the prevention and management of influenza in people with
asthma, we performed a scoping review of the published literature on influenza burden; …

Immobilization induces anabolic resistance in human myofibrillar protein synthesis with low and high dose amino acid infusion

EI Glover, SM Phillips, BR Oates, JE Tang… - The Journal of …, 2008 - Wiley Online Library
We tested the hypothesis that increasing blood amino acid (AA) availability would counter
the physical inactivity‐induced reduction in muscle protein synthesis. We determined how …

[HTML][HTML] Muscle full effect after oral protein: time-dependent concordance and discordance between human muscle protein synthesis and mTORC1 signaling

PJ Atherton, T Etheridge, PW Watt, D Wilkinson… - The American journal of …, 2010 - Elsevier
Background: We previously showed that human muscle protein synthesis (MPS) increased
during infusion of amino acids (AAs) and peaked at≈ 120 min before returning to baseline …

Architectural, functional and molecular responses to concentric and eccentric loading in human skeletal muscle

MV Franchi, PJ Atherton, ND Reeves, M Flück… - Acta …, 2014 - Wiley Online Library
Aim We investigated architectural, functional and molecular responses of human skeletal
muscle to concentric (CON) or eccentric (ECC) resistance training (RT). Methods Twelve …

The temporal responses of protein synthesis, gene expression and cell signalling in human quadriceps muscle and patellar tendon to disuse

MD De Boer, A Selby, P Atherton, K Smith… - The Journal of …, 2007 - Wiley Online Library
We hypothesized that rates of myofibrillar and patellar tendon collagen synthesis would fall
over time during disuse, the changes being accompanied in muscle by decreases in focal …

[HTML][HTML] Blunting of insulin inhibition of proteolysis in legs of older subjects may contribute to age-related sarcopenia

EA Wilkes, AL Selby, PJ Atherton, R Patel… - The American journal of …, 2009 - Elsevier
Background Reduced postprandial muscle proteolysis is mainly due to increased insulin
availability. Whether rates of proteolysis in response to low physiologic doses of insulin are …