After asthma: redefining airways diseases
Executive summary Asthma is responsible for considerable global morbidity and health-care
costs. Substantial progress was made against key outcomes such as hospital admissions …
costs. Substantial progress was made against key outcomes such as hospital admissions …
Early identification of atopy in the prediction of persistent asthma in children
The long-term solution to the asthma epidemic is thought to be prevention, and not treatment
of established disease. Atopic asthma arises from gene–environment interactions, which …
of established disease. Atopic asthma arises from gene–environment interactions, which …
Vitamin D modulation of innate immune responses to respiratory viral infections
MT Zdrenghea, H Makrinioti… - Reviews in medical …, 2017 - Wiley Online Library
Vitamin D, in addition to its classical functions in bone homeostasis, has a modulatory and
regulatory role in multiple processes, including host defense, inflammation, immunity, and …
regulatory role in multiple processes, including host defense, inflammation, immunity, and …
[HTML][HTML] Disordered microbial communities in asthmatic airways
Background A rich microbial environment in infancy protects against asthma, and infections
precipitate asthma exacerbations. We compared the airway microbiota at three levels in …
precipitate asthma exacerbations. We compared the airway microbiota at three levels in …
Recommendations for the assessment and management of cough in children
MD Shields, A Bush, ML Everard, S McKenzie… - Thorax, 2008 - thorax.bmj.com
Community-based surveys show that parentalreported cough as an isolated symptom has a
high prevalence. 2 3 Reported cough without colds has a prevalence of 28% in boys and …
high prevalence. 2 3 Reported cough without colds has a prevalence of 28% in boys and …
Management of severe asthma: a European respiratory society/American thoracic society guideline
This document provides clinical recommendations for the management of severe asthma.
Comprehensive evidence syntheses, including meta-analyses, were performed to …
Comprehensive evidence syntheses, including meta-analyses, were performed to …
Respiratory syncytial virus load, viral dynamics, and disease severity in previously healthy naturally infected children
CM El Saleeby, AJ Bush, LM Harrison… - Journal of Infectious …, 2011 - academic.oup.com
Background. Respiratory syncytial virus (RSV) disease severity was thought to be a result of
host immunopathology but alternatively may be driven by high-level viral replication. The …
host immunopathology but alternatively may be driven by high-level viral replication. The …
Expiratory airflow in late adolescence and early adulthood in individuals born very preterm or with very low birthweight compared with controls born at term or with …
Background Maximal expiratory airflow peaks early in the third decade of life, then gradually
declines with age. The pattern of airflow through adulthood for individuals born very preterm …
declines with age. The pattern of airflow through adulthood for individuals born very preterm …
At-risk children with asthma (ARC): a systematic review
Introduction Asthma attacks are responsible for considerable morbidity and may be fatal. We
aimed to identify and weight risk factors for asthma attacks in children (5–12 years) in order …
aimed to identify and weight risk factors for asthma attacks in children (5–12 years) in order …
International management platform for children's interstitial lung disease (chILD-EU)
M Griese, E Seidl, M Hengst, S Reu, H Rock… - Thorax, 2018 - thorax.bmj.com
Background Children's interstitial lung diseases (chILD) cover many rare entities, frequently
not diagnosed or studied in detail. There is a great need for specialised advice and for …
not diagnosed or studied in detail. There is a great need for specialised advice and for …