A significant increase in life expectancy in successive birth cohorts of people with cystic
fibrosis (CF) is a result of more effective treatment for the disease. It is also now widely …

Background: A sensitive and valid non-invasive marker of early cystic fibrosis (CF) lung
disease is sought. The lung clearance index (LCI) from multiple-breath washout (MBW) is …

The median age of the population with cystic fibrosis (CF) has increased worldwide, which
has led to the suggestion that the prevalence of liver disease would increase. The aim of this …

Background: A study was undertaken to compare the ability of computed tomographic (CT)
scores and pulmonary function tests to detect changes in lung disease in children and adults …

Mycobacterium abscessus has been isolated increasingly often from the respiratory tracts of
cystic fibrosis (CF) patients. It is not known whether these organisms are transmitted from …

The improved survival in people with cystic fibrosis has led to an increasing number of
patients reaching adulthood. This trend is likely to be maintained over the next decades …

The lung clearance index (LCI) is a lung function parameter derived from the multiple-breath
washout (MBW) test. Although first developed 60 years ago, the technique was not widely …

The efficacy of 2 years of treatment with ursodeoxycholic acid (UDCA) in cystic fibrosis (CF)-
associated liver disease was evaluated by liver biopsies and liver function tests in 10 …

Background Monitoring changes in the epidemiology of cystic fibrosis (CF) pathogens is
essential for clinical research, quality improvement, and clinical management. Methods We …

Background Viral infections can cause significant morbidity in cystic fibrosis (CF). The
current Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic could …