Introduction: Asthma is a major disease burden worldwide. Treatment with steroids and long
acting β-agonists effectively manage symptoms in many patients but do not treat the …

Airway inflammation underpins the pathogenesis of the major human chronic respiratory
diseases. It is now well recognized that respiratory infections with bacteria and viruses are …

A subset of patients with stable asthma has prominent neutrophilic and reduced eosinophilic
inflammation, which is associated with attenuated airways hyper-responsiveness (AHR) …

Background 20–30% of patients with asthma have neutrophilic airway inflammation and
reduced responsiveness to steroid therapy. They often have chronic airway bacterial …

Background Steroid-insensitive endotypes of asthma are an important clinical problem and
effective therapies are required. They are associated with bacterial infection and non …

Pathogenic bacterial infections of the lung are life threatening and underpin chronic lung
diseases. Current treatments are often ineffective potentially due to increasing antibiotic …

Asthma is a common inflammatory disease of the airways. Current therapies alleviate
symptoms but do not treat the disease. We aim to develop effective immunomodulatory …

Nontypeable Haemophilus influenzae (NTHi) is a prevalent bacterium found in a variety of
chronic respiratory diseases. The role of this bacterium in the pathogenesis of lung …

Background and objective Chronic obstructive pulmonary disease (COPD) is characterized
by progressive airflow limitation and inflammation. Airway bacterial colonization is increased …

Abstract Background and Objective Neutrophil elastase (NE), is an important host defence
against lung pathogens. Maintaining a homeostatic balance between proteases such as NE …