The diagnosis, investigation and particularly management of bronchiectasis has been
largely empirical and the subject of relatively few controlled clinical trials. There are no clear …

Background Unexplained chronic cough (UCC) causes significant impairments in quality of
life. Effective assessment and treatment approaches are needed for UCC. Methods This …

Bronchopulmonary C-fibers and a subset of mechanically sensitive, acid-sensitive
myelinated sensory nerves play essential roles in regulating cough. These vagal sensory …

Bronchiectasis in adults is a chronic disorder associated with poor quality of life and frequent
exacerbations in many patients. There have been no previous international guidelines. The …

Rationale: There are no risk stratification tools for morbidity and mortality in bronchiectasis.
Identifying patients at risk of exacerbations, hospital admissions, and mortality is vital for …

PURPOSE: Viable bacteria are often isolated from airway secretions in clinically stable
patients with chronic bronchitis. We hypothesized that the number of organisms and …

CT scanning can also aid in identifying an aetiology of bronchiectasis eg Allergic
bronchopulmonary aspergillosis (ABPA), Non-tuberculous mycobacteria (NTM), primary …

BACKGROUND: C-reactive protein (CRP) is an acute phase protein synthesized by the liver
primarily in response to interleukin-6. Initial studies have suggested that inflammatory …

Background We performed systematic reviews using the population, intervention,
comparison, outcome (PICO) format to answer the following key clinical question: Are the …

Rationale: The vicious cycle hypothesis of bronchiectasis argues that bacterial colonization
leads to airway inflammation and progressive lung damage. The logical extension of this …