Background: Lung clearance index (LCI), a measure of ventilation inhomogeneity derived
from the multiple-breath inert gas washout (MBW) technique, has been shown to detect …

We examined whether the adverse effects of prenatal exposure to tobacco on lung
development are limited to the last weeks of gestation by comparing respiratory function in …

Background Long-term benefits of newborn screening (NBS) for cystic fibrosis (CF) have
been established with respect to nutritional status, but effects on pulmonary health remain …

The lung clearance index (LCI) is more sensitive than spirometry in detecting abnormal lung
function in children with cystic fibrosis. LCI is thought to be independent of age, but recent …

Measurements of maximal flow at functional residual capacity (V˙ max FRC) from partial
forced expiratory maneuvers remain the most popular method for assessing small airway …

Rationale: After recent standardization of forced expiratory maneuvers for both infants and
preschool children, longitudinal measurements are now possible from birth. Objectives: The …

Rationale Newborn screening (NBS) for cystic fibrosis (CF) allows early intervention. Design
of randomised controlled trials (RCT) is currently impeded by uncertainty regarding …

This study aimed to investigate the evolution of airway function in infants newly diagnosed
with cystic fibrosis (CF). FEV0. 5 was measured soon after diagnosis (median age of 28 …

Objective: To assess airway function at 1 year and compare this with similar measurements
made shortly after birth in preterm infants without clinical neonatal respiratory disease. Study …

Background: Poor fetal growth has been associated with impaired airway function in adult
life, but evidence linking birth weight and airway function in early childhood is sparse. We …