The endothelium, a cellular monolayer lining the blood vessel wall, plays a critical role in
maintaining multiorgan health and homeostasis. Endothelial functions in health include …

Excessive airway obstruction is the cause of symptoms and abnormal lung function in
asthma. As airway smooth muscle (ASM) is the effecter controlling airway calibre, it is …

Increased airway smooth muscle (ASM) mass is perhaps the most important component of
the airway wall remodeling process in asthma. Known mediators of ASM proliferation in cell …

Proteins are translated in the cytoplasm, but many need to access the nucleus to perform
their functions. Understanding how these nuclear proteins are transported through the …

Background The refractive index (RI) of cellular material provides fundamental biophysical
information about the composition and organizational structure of cells. Efforts to describe …

Non-alcoholic steatohepatitis (NASH) develops from non-alcoholic fatty liver disease
(NAFLD). Currently, around 25% of the population is estimated to have NAFLD, and 25% of …

Granulocyte-macrophage colony-stimulating factor (GM-CSF) stimulates hemopoiesis and
effector functions of granulocytes and macrophages and is involved in pulmonary surfactant …

Membrane proteins reside in lipid bilayers and are typically extracted from this environment
for study, which often compromises their integrity. In this work, we ejected intact assemblies …

Achromobacter is a genus of nonfermenting Gram-negative bacteria under order
Burkholderiales. Although primarily isolated from respiratory tract of people with cystic …

A molecular model that provides a framework for interpreting the wealth of functional
information obtained on the E. coli F-ATP synthase has been generated using cryo-electron …