Allergic rhinitis, asthma, and atopic eczema are among the commonest causes of chronic ill
health. These diseases are increasing in prevalence, and they add considerably to the …

Eosinophils are pleiotropic multifunctional leukocytes involved in initiation and propagation
of diverse inflammatory responses, as well as modulators of innate and adaptive immunity …

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ARTICLECredit can now be obtained, free for a limited time, by reading the following review …

Background. In atopic asthma, activated T helper lymphocytes are present in bronchial-
biopsy specimens and bronchoalveolar-lavage (BAL) fluid, and their production of cytokines …

We have used immunohistochemistry and monoclonal antibodies to analyze the phenotypic
composition and activation status of the cellular infiltrate of bronchial biopsies obtained by …

Bronchial biopsy specimens were obtained by fiberoptic bronchoscopy from 21 atopic
subjects with asthma, 10 atopic subjects without asthma, and 12 normal healthy control …

We have undertaken a cross-sectional study of 2 groups of subjects with mild atopic asthma.
One group wassymptomatic at the time of lavage and the other group was asymptomatic …

Little is known of the structural changes in mild asthma. We have studied the light and
electron microscopic structure of lobar bronchial biopsies taken at fiberoptic bronchoscopy …

Eosinophil-derived TGF-β has been implicated in remodeling events in asthma. We
hypothesized that reduction of bronchial mucosal eosinophils with anti–IL-5 would reduce …

The role of eosinophils as effector cells in asthma pathogenesis has been questioned since
an anti–interleukin (IL)-5 monoclonal antibody (mepolizumab), which depleted blood and …