Exposure to inorganic particles in paediatric sarcoidosis: the PEDIASARC study

Nadia Nathan; Marie-Emeline Montagne; Odile Macchi; Paul-André Rosental; Simon Chauveau; Florence Jeny; Lucile Sesé; Rola Abou Taam; Manon Brocvielle; Jacques Brouard; Mickaël Catinon; Catherine Chapelon-Abric; Fleur Cohen-Aubart; Christophe Delacourt; Céline Delestrain; Antoine Deschildre; Antoine Dossier; Ralph Epaud; Julien Haroche; Véronique Houdouin; Dominique Israel-Biet; Karine Juvin; Sylvain Le Jeune; Francois Lionnet; Ulrich Meinzer; Marie Mittaine; Hilario Nunes; Sarah Mattioni; Jean-Marc Naccache; Marie-Hélène Odièvre; Michel Vincent; Annick Clement; Dominique Valeyre; Catherine Cavalin; French Sarcoidosis Group and the Silicosis Research Group

doi:10.1136/thoraxjnl-2021-217870

Exposure to inorganic particles in paediatric sarcoidosis: the PEDIASARC study

Thorax. 2022 Apr;77(4):404-407. doi: 10.1136/thoraxjnl-2021-217870. Epub 2021 Oct 21.

Authors

Nadia Nathan^#¹, Marie-Emeline Montagne^#², Odile Macchi³, Paul-André Rosental⁴, Simon Chauveau⁵, Florence Jeny⁵, Lucile Sesé⁵, Rola Abou Taam⁶, Manon Brocvielle⁷, Jacques Brouard⁸, Mickaël Catinon⁹, Catherine Chapelon-Abric¹⁰, Fleur Cohen-Aubart¹¹, Christophe Delacourt⁶, Céline Delestrain¹², Antoine Deschildre¹³, Antoine Dossier¹⁴, Ralph Epaud¹⁵, Julien Haroche¹¹, Véronique Houdouin¹⁶, Dominique Israel-Biet¹⁷, Karine Juvin¹⁷, Sylvain Le Jeune¹⁸, Francois Lionnet¹⁹, Ulrich Meinzer²⁰, Marie Mittaine²¹, Hilario Nunes⁵, Sarah Mattioni¹⁹, Jean-Marc Naccache²², Marie-Hélène Odièvre²³, Michel Vincent⁹, Annick Clement²⁴, Dominique Valeyre^{5

25}, Catherine Cavalin^{26

27

28}; French Sarcoidosis Group and the Silicosis Research Group

Affiliations

¹ Pediatric Pulmonology Department and Reference Center for Rare Lung Diseases RespiRare, Inserm UMR_S933 Laboratory of Childhood Genetic Diseases, Armand Trousseau Hospital, AP-HP. Sorbonne Université, Paris, France nadia.nathan@aphp.fr.
² Pediatric Pulmonology Department and Reference Center for Rare Lung Diseases RespiRare, Armand Trousseau Hospital, AP-HP. Sorbonne Université, Paris, France.
³ Observatoire, Samu Social de Paris, Paris, France.
⁴ Centre d'Histoire, Sciences Po, Paris, France.
⁵ Pulmonology Department and Inserm UMR 127, Avicenne Hospital, APHP. Université Sorbonne Paris Nord, Paris, France.
⁶ Pediatric Pulmonology Department and Reference Center for Rare Lung Diseases RespiRare, Necker Enfants Malades Hospital, AP-HP. Centre - Université de Paris, Paris, France.
⁷ Statistician, Marcq-en-Baroeul, France.
⁸ Pediatric Pulmonology Department, CHU Caen, Caen, France.
⁹ MINAPATH : SAS sociale et solidaire, Lyon, France.
¹⁰ Department of Internal Medicine and Clinical Immunology, La Pitié-Salpêtrière Hospital, APHP. Sorbonne Université, Paris, France.
¹¹ Department of Internal Medicine 2, La Pitié-Salpêtrière Hospital, e3m Institute, Reference Center for Rare Systemic Diseases, Lupus, Anti-Phospholipids Syndrome, AP-HP. Sorbonne Université, Paris, France.
¹² Pediatric Department and Reference Center for Rare Lung Diseases RespiRare, INSERM, IMRB, Centre Hospitalier Intercommunal de Créteil, Université Paris Est Creteil, Paris, France.
¹³ Pediatric pulmonology and allergy department, Hôpital Jeanne de Flandre, Université de Lille, Lille, France.
¹⁴ Department of Internal Medicine, Bichat Hospital, AP-HP. Nord - Université de Paris, Paris, France.
¹⁵ Centre Hospitalier Intercommunal de Créteil, Pediatric Department and Reference center for rare lung diseases (RespiRare), INSERM, IMRB, Université Paris Est Creteil, Paris, France.
¹⁶ Pediatric Pulmonology department, Robert Debré Hospital, AP-HP. Nord - Université de Paris, Paris, France.
¹⁷ Pulmonology department, Georges Pompidou Hospital, AP-HP. Centre - Université de Paris, Paris, France.
¹⁸ Department of Internal Medicine, Avicenne Hospital, APHP. Université Sorbonne Paris Nord, Paris, France.
¹⁹ Department of Internal Medicine, Tenon Hospital, AP-HP. Sorbonne Université, Paris, France.
²⁰ Department of General Pediatrics, Pediatric Internal Medicine, Rheumatology and Infectious Diseases, National Referee Center for Rare Pediatric Inflammatory Rheumatisms and Systemic Auto-Immune Diseases RAISE, Robert Debré Hospital, AP-HP. Nord - Université de Paris, Paris, France.
²¹ Pediatric Pulmonology Department, Children Hospital, CHU Toulouse, Toulouse, France.
²² Pulmonology Department, Groupe hospitalier Paris Saint-Joseph and Hôpital Foch, Paris, France.
²³ Department of Pediatrics and Sickle Cell Disease Center, Armand Trousseau Hospital, AP-HP. Sorbonne Université, Paris, France.
²⁴ Pediatric Pulmonology Department and Reference Center for Rare Lung Diseases RespiRare, Inserm UMR_S933 Laboratory of Childhood Genetic Diseases, Armand Trousseau Hospital, AP-HP. Sorbonne Université, Paris, France.
²⁵ Pulmonology department, Paris Saint Joseph Hospital Group, Paris, France.
²⁶ Institut de recherche interdisciplinaire en sciences sociales (IRISSO, UMR CNRS-INRA 7170-1427), Université Paris Dauphine, PSL, Paris, France.
²⁷ Laboratoire interdisciplinaire d'évaluation des politiques publiques (LIEPP), Sciences Po, Paris, France.
²⁸ Centre d'études de l'emploi et du travail (CEET, CNAM), CNAM, Paris, France.

^# Contributed equally.

PMID: 34675126
DOI: 10.1136/thoraxjnl-2021-217870

Abstract

Inorganic antigens may contribute to paediatric sarcoidosis. Thirty-six patients matched with 36 healthy controls as well as a group of 21 sickle-cell disease (SCD) controls answered an environmental questionnaire. Patients' indirect exposure to inorganic particles, through coresidents' occupations, was higher than in healthy and SCD controls (median score: 2.5 (0.5-7) vs 0.5 (0-2), p=0.003 and 1 (0-2), p=0.012, respectively), especially for construction, exposures to metal dust, talc, abrasive reagents and scouring products. Wood or fossil energies heating were also linked to paediatric sarcoidosis. This study supports a link between mineral environmental exposure due to adult coresident occupations and paediatric sarcoidosis.

Keywords: occupational lung disease; paediatric interstitial lung disease; rare lung diseases; sarcoidosis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Child
Dust
Environmental Exposure / adverse effects
Humans
Occupational Exposure* / adverse effects
Occupations
Sarcoidosis*
Talc

Substances

Dust
Talc