Abstract
Nonsteroidal anti-inflammatory drugs (NSAIDs) suppress colon carcinogenesis in man and experimental animals. However, conventional NSAIDs inhibit both cyclooxygenase (COX) isoforms, COX-1 and COX-2, and cause gastrointestinal side-effects. Nimesulide, a selective inhibitor of COX-2, is much less ulcerogenic. We, therefore, examined its influence on the development of intestinal polyps in Min mice. Female Min mice at 4 weeks old were given 400 ppm nimesulide in their diet for 11 weeks. This treatment resulted in a significant reduction of the numbers of both small and large intestinal polyps, the total being 52% of that in untreated control Min mice. The size of the polyps in the nimesulide-treated group was also significantly decreased. The results suggest that nimesulide is a good candidate as a chemopreventive agent for human colon cancer with low toxicity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology
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Anticarcinogenic Agents / chemistry
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Anticarcinogenic Agents / therapeutic use*
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Colon / drug effects
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Cyclooxygenase 2
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Cyclooxygenase 2 Inhibitors
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Cyclooxygenase Inhibitors / chemistry
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Cyclooxygenase Inhibitors / therapeutic use*
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Drug Screening Assays, Antitumor
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Female
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Intestinal Neoplasms / pathology
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Intestinal Neoplasms / prevention & control*
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Intestinal Polyps / pathology
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Intestinal Polyps / prevention & control*
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Isoenzymes / drug effects*
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Isoenzymes / metabolism
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Mice
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Mice, Inbred C57BL
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Prostaglandin-Endoperoxide Synthases / drug effects*
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Prostaglandin-Endoperoxide Synthases / metabolism
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Sulfonamides / chemistry
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Sulfonamides / therapeutic use*
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Anticarcinogenic Agents
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Cyclooxygenase 2 Inhibitors
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Cyclooxygenase Inhibitors
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Isoenzymes
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Sulfonamides
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Cyclooxygenase 2
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Prostaglandin-Endoperoxide Synthases
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nimesulide