Abstract
The nervous system is involved in approximately 25% of patients with classical Wegener's granulomatosis. The spectrum of this disease has been broadened with the discovery of the anti-neutrophil cytoplasmic antibodies, which are found in diseases sharing many clinical features. The ANCA testing may indicate a common mode of pathogenesis. The definitive diagnostic marker is histological, and that forms the best guide to specific therapy.
MeSH terms
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Adrenal Cortex Hormones / therapeutic use
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Alkylating Agents / therapeutic use
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Anti-Infective Agents / therapeutic use
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Antibodies, Antineutrophil Cytoplasmic / immunology*
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Antimetabolites, Antineoplastic / therapeutic use
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Cyclophosphamide / therapeutic use
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Granulomatosis with Polyangiitis / drug therapy
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Granulomatosis with Polyangiitis / immunology*
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Humans
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Methotrexate / therapeutic use
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Prognosis
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Recurrence
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Sulfamethoxazole / therapeutic use
Substances
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Adrenal Cortex Hormones
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Alkylating Agents
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Anti-Infective Agents
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Antibodies, Antineutrophil Cytoplasmic
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Antimetabolites, Antineoplastic
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Cyclophosphamide
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Sulfamethoxazole
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Methotrexate