Chest radiographic data acquisition and quality assurance in multicenter studies

Pediatr Radiol. 1997 Nov;27(11):880-7. doi: 10.1007/s002470050262.

Abstract

Background: Multicenter studies rely on data derived from different institutions. Forms can be designed to standardize the reporting process allowing reliable comparison of data.

Objective: The purpose of the report is to provide a standardized method, developed as a part of a multicenter study of vertically transmitted HIV, for assessing chest radiographic results.

Materials and methods: Eight hundred and five infants and children were studied at five centers; 3057 chest radiographs were scored. Data were entered using a forced-choice, graded response for 12 findings. Quality assurance measures and inter-rater agreement statistics are reported.

Results: The form used for reporting chest radiographic results is presented. Inter-rater agreement was moderate to high for most findings, with the best correlation reported for the presence of bronchovascular markings and/or reticular densities addressed as a composite question (kappa = 0.71). The presence of nodular densities (kappa = 0.56) and parenchymal consolidation (kappa = 0.57) had moderate agreement. Agreement for lung volume was low.

Conclusion: The current tool, developed for use in the pediatric population, is applicable to any study involving the assessment of pediatric chest radiographs for a large population, whether at one or many centers.

Publication types

  • Clinical Trial
  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Child
  • Child, Preschool
  • Follow-Up Studies
  • HIV Infections / diagnostic imaging
  • HIV Infections / transmission
  • HIV-1
  • Humans
  • Infant
  • Infectious Disease Transmission, Vertical
  • Medical Records
  • Observer Variation
  • Quality Assurance, Health Care*
  • Radiography, Thoracic / standards*
  • Radiography, Thoracic / statistics & numerical data
  • United States