Linear growth of very young asthmatic children treated with high-dose nebulized budesonide

Acta Paediatr. 1996 Apr;85(4):421-4. doi: 10.1111/j.1651-2227.1996.tb14053.x.

Abstract

The aim of this open study was to observe linear growth in young children with asthma treated with nebulized budesonide. Infants and young children (< 3 years old) with severe uncontrolled asthma were studied. They were treated with nebulized budesonide (1-4 mg day-1) and treated for at least 6 months. Height standard deviation scores (HtSDS) were measured before ("pre-measurements") immediately prior to commencing nebulized budesonide therapy (baseline) and after at least 6 months of therapy ("post-measurements"). The mean HtSDS score at pretreatment was -0.21 and at baseline had fallen further to -0.46. The mean HtSDS increased to -0.17 when the post-measurements were made (p = 0.035) after at least 6 months of nebulized budesonide therapy. Treatment with nebulized budesonide for longer than 6 months in very young children with severe asthma was not associated with reduced linear growth.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Inhalation
  • Age Factors
  • Asthma / drug therapy*
  • Body Height / drug effects*
  • Bronchodilator Agents / administration & dosage
  • Bronchodilator Agents / adverse effects*
  • Budesonide
  • Child, Preschool
  • Growth Disorders / chemically induced*
  • Humans
  • Infant
  • Nebulizers and Vaporizers
  • Pregnenediones / administration & dosage
  • Pregnenediones / adverse effects*
  • Prospective Studies
  • Time Factors

Substances

  • Bronchodilator Agents
  • Pregnenediones
  • Budesonide