Stomach as source of bacteria colonising respiratory tract during artificial ventilation

Lancet. 1978 Nov 4;2(8097):968-9. doi: 10.1016/s0140-6736(78)92530-8.

Abstract

10 adults had intermittent positive-pressure ventilation for 3--34 days. All 10 had paralytic ileus. Microbial overgrowth in the stomach was found in 9 patients (bacterial in 7 and fungal in 2); gram-negative bacteria predominated. The trachea invariably became colonised by bacteria, mainly gram-negative organisms. In 3 instances the gram-negative bacteria were found in the stomach before they appeared in the tracheal aspirate, and in 1 case the pathogen originated in the faeces.

MeSH terms

  • Adult
  • Aged
  • Candida albicans / isolation & purification
  • Candidiasis / etiology
  • Enterobacteriaceae Infections / etiology
  • Enterococcus faecalis / isolation & purification
  • Escherichia coli / isolation & purification
  • Humans
  • Intermittent Positive-Pressure Breathing / adverse effects*
  • Klebsiella pneumoniae / isolation & purification
  • Middle Aged
  • Positive-Pressure Respiration / adverse effects*
  • Proteus mirabilis / isolation & purification
  • Pseudomonas Infections / etiology
  • Sepsis / etiology*
  • Staphylococcal Infections / etiology
  • Staphylococcus / isolation & purification
  • Stomach / microbiology*
  • Streptococcal Infections / etiology
  • Toxemia / etiology*
  • Trachea / microbiology*