Acute hypoxemic respiratory failure following intrapleural thrombolytic therapy for hemothorax

M D Frye; M Jarratt; S A Sahn

doi:10.1378/chest.105.5.1595

Acute hypoxemic respiratory failure following intrapleural thrombolytic therapy for hemothorax

Chest. 1994 May;105(5):1595-6. doi: 10.1378/chest.105.5.1595.

Authors

M D Frye¹, M Jarratt, S A Sahn

Affiliation

¹ Division of Pulmonary and Critical Care Medicine, Medical University of South Carolina, Charleston.

PMID: 8181368
DOI: 10.1378/chest.105.5.1595

Abstract

Intrapleural instillation of thrombolytic agents has been useful in the treatment of hemothorax when thoracostomy tube drainage is unsuccessful. We present a patient who developed acute hypoxemic respiratory failure following the intrapleural instillation of both streptokinase and urokinase 24 h apart. Hypoxemia most likely resulted from a direct effect of the products of fibrinolysis on the pulmonary circulation.

Publication types

Case Reports

MeSH terms

Acute Disease
Hemothorax / drug therapy*
Humans
Hypoxia / chemically induced*
Instillation, Drug
Male
Middle Aged
Pleura
Respiratory Insufficiency / chemically induced*
Streptokinase / administration & dosage
Streptokinase / adverse effects
Thrombolytic Therapy / adverse effects*
Urokinase-Type Plasminogen Activator / administration & dosage
Urokinase-Type Plasminogen Activator / adverse effects

Substances

Streptokinase
Urokinase-Type Plasminogen Activator