Abstract
Substances which are commonly sucked or chewed in two areas where the incidence of oesophageal cancer is high, the Transkei and north-east Iran, were tested in bacterial mutagenicity assays. Pyrolysed substances, opium dross in north-east Iran and tobacco pipe residues in the Transkei, displayed mutagenic activity in Salmonella typhimurium strains TA98 and TA100 in the presence of rat liver microsomes.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Administration, Oral
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Adult
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Animals
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Cells, Cultured
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Esophageal Neoplasms / chemically induced*
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Female
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Humans
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Iran
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Male
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Microsomes, Liver
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Mutagens* / administration & dosage
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Mutation / drug effects
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Nicotiana*
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Opium / administration & dosage
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Opium / adverse effects*
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Plants, Toxic*
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Rats
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Salmonella typhimurium / drug effects
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Salmonella typhimurium / genetics
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Smoking / complications*
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South Africa