Abstract
Bordetella pertussis organisms, with or without a small dose of alumhydroxide, enhance in rats the production of IgE antibodies to an unrelated antigen, even if this antigen has been administered 6 weeks beforehand. This non-specific enhancement of IgE antibodies is accompanied by a substantial rise in total serum IgE and by the production of IgE antibodies to B. pertussis. The effect of B. pertussis on IgE synthesis is dose-dependent. No effect of B. pertussis on IgE production can be observed in nude rats.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adjuvants, Immunologic / administration & dosage*
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Aluminum Hydroxide / administration & dosage
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Aluminum Hydroxide / immunology
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Animals
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Antibody Specificity
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Disease Models, Animal
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Dose-Response Relationship, Immunologic
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Immunoglobulin E / analysis
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Immunoglobulin E / biosynthesis*
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Ovalbumin / immunology
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Pertussis Vaccine / administration & dosage*
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Pertussis Vaccine / immunology
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Rats
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Rats, Inbred BN
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Rats, Inbred Strains
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Rats, Mutant Strains
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Respiratory Hypersensitivity / immunology*
Substances
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Adjuvants, Immunologic
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Pertussis Vaccine
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Immunoglobulin E
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Aluminum Hydroxide
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Ovalbumin