Autoradiographic visualization of muscarinic receptors in pulmonary nerves and ganglia

C J van Koppen; W M Blankesteijn; A B Klaassen; J F Rodrigues de Miranda; A J Beld; C A van Ginneken

doi:10.1016/0304-3940(87)90092-9

Autoradiographic visualization of muscarinic receptors in pulmonary nerves and ganglia

Neurosci Lett. 1987 Dec 29;83(3):237-40. doi: 10.1016/0304-3940(87)90092-9.

Authors

C J van Koppen¹, W M Blankesteijn, A B Klaassen, J F Rodrigues de Miranda, A J Beld, C A van Ginneken

Affiliation

¹ Department of Pharmacology, University of Nijmegen, The Netherlands.

PMID: 3441306
DOI: 10.1016/0304-3940(87)90092-9

Abstract

We investigated autoradiographically the distribution of muscarinic receptors in bovine airways using (-)-[3H]quinuclidinyl benzilate as radioligand. The autoradiographs demonstrated the presence of muscarinic receptors in smooth muscle as well as neuronal muscarinic receptors in pulmonary nerves and ganglia. It is reasonable to believe that the neuronal muscarinic receptors participate in the regulation of neurotransmitter release at the peripheral nerve terminals innervating the bronchial smooth muscle.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Autoradiography
Cattle
Ganglia / analysis*
Lung / innervation*
Muscle, Smooth / analysis
Muscle, Smooth / innervation
Receptors, Muscarinic / analysis*

Substances

Receptors, Muscarinic