Immunological complications of obesity

Nat Immunol. 2012 Jul 19;13(8):707-12. doi: 10.1038/ni.2343.

Abstract

Current approaches for the treatment of obesity, including diet and lifestyle changes, have not been successful in curtailing the obesity epidemic. The higher incidence of inflammation-associated chronic disease and greater susceptibility to infection in obese people represents a growing health threat. Improved understanding of the immunological processes that regulate obesity may yield new treatments for obesity-associated disorders.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipose Tissue / immunology*
  • B-Lymphocytes / immunology
  • Biological Evolution
  • Diet
  • Humans
  • Inflammasomes / immunology
  • Inflammasomes / metabolism
  • Leukocytosis*
  • Life Style
  • Macrophage Activation
  • Macrophages / immunology
  • Mast Cells / immunology
  • Neutrophils / immunology
  • Obesity / complications
  • Obesity / immunology*
  • T-Lymphocytes / immunology

Substances

  • Inflammasomes