Abstract
The effect of acute oral administration of 2 g vitamin C on bronchial responsiveness to inhaled histamine in 16 patients with allergic rhinitis was compared with placebo on two consecutive days in a double-blind, crossover design. The PC15FEV1 was significantly increased one hour after treatment with vitamin C but not after placebo.
Publication types
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Clinical Trial
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Controlled Clinical Trial
MeSH terms
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Administration, Inhalation
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Adult
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Ascorbic Acid / blood
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Ascorbic Acid / pharmacology*
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Bronchi / drug effects*
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Double-Blind Method
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Female
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Forced Expiratory Volume
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Histamine / administration & dosage*
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Humans
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Male
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Maximal Expiratory Flow Rate
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Rhinitis, Allergic, Seasonal / drug therapy
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Rhinitis, Allergic, Seasonal / physiopathology*